CYLD (gene)

CYLD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IXD, 1WHL, 1WHM, 2VHF
Identifiers
Aliases	CYLD, BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, CYLD lysine 63 deubiquitinase
External IDs	OMIM: 605018; MGI: 1921506; HomoloGene: 9069; GeneCards: CYLD; OMA:CYLD - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q12.1 Start 50,742,050 bp End 50,801,935 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C3 Start 89,423,656 bp End 89,478,573 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus Achilles tendon lymph node cartilage tissue external globus pallidus sperm middle temporal gyrus pars reticulata tonsil pars compacta Top expressed in otolith organ utricle olfactory tubercle nucleus accumbens lateral septal nucleus mesenteric lymph nodes ventromedial nucleus anterior amygdaloid area otic vesicle medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity zinc ion binding metal ion binding peptidase activity protein binding thiol-dependent deubiquitinase proline-rich region binding hydrolase activity protein kinase binding Lys63-specific deubiquitinase activity Lys48-specific deubiquitinase activity structural constituent of ribosome Cellular component cytoplasm cytosol centrosome cell projection membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane spindle microtubule organizing center midbody perinuclear region of cytoplasm cytoplasmic microtubule cytoskeleton microtubule ciliary basal body ciliary tip Biological process regulation of intrinsic apoptotic signaling pathway ubiquitin-dependent protein catabolic process regulation of microtubule cytoskeleton organization Wnt signaling pathway proteolysis protein K63-linked deubiquitination regulation of mitotic cell cycle positive regulation of extrinsic apoptotic signaling pathway cell cycle negative regulation of type I interferon production negative regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing signaling pathway negative regulation of canonical Wnt signaling pathway immune system process regulation of tumor necrosis factor-mediated signaling pathway protein deubiquitination CD4-positive or CD8-positive, alpha-beta T cell lineage commitment regulation of protein binding innate immune response regulation of B cell differentiation negative regulation of T cell differentiation positive regulation of T cell differentiation homeostasis of number of cells positive regulation of T cell receptor signaling pathway necroptosis protein K48-linked deubiquitination ripoptosome assembly involved in necroptotic process regulation of cilium assembly positive regulation of protein localization protein linear deubiquitination cytoplasmic translation negative regulation of NIK/NF-kappaB signaling negative regulation of JNK cascade negative regulation of p38MAPK cascade regulation of inflammatory response regulation of necroptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1540 74256 Ensembl ENSG00000083799 ENSMUSG00000036712 UniProt Q9NQC7 Q80TQ2 RefSeq (mRNA) NM_001042355 NM_001042412 NM_015247 NM_001128169 NM_001128170 NM_001128171 NM_001276279 NM_173369 RefSeq (protein) NP_001035814 NP_001035877 NP_056062 NP_001365672 NP_001365673 NP_001365674 NP_001365675 NP_001365676 NP_001365677 NP_001365678 NP_001365679 NP_001365680 NP_001365681 NP_001365682 NP_001365683 NP_001365684 NP_001035814.1 NP_001035877.1 NP_001121642 NP_001121643 NP_001263208 NP_775545 Location (UCSC) Chr 16: 50.74 – 50.8 Mb Chr 8: 89.42 – 89.48 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cylindromatosis (turban tumor syndrome), also known as CYLD, is a human gene.