CYLD (gene)

From Wikipedia, the free encyclopedia
  (Redirected from Cylindromatosis)
Jump to: navigation, search
CYLD
Protein CYLD PDB 1ixd.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CYLD, BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, CYLD lysine 63 deubiquitinase
External IDs MGI: 1921506 HomoloGene: 9069 GeneCards: CYLD
RNA expression pattern
PBB GE CYLD 214272 at tn.png

PBB GE CYLD 221903 s at tn.png

PBB GE CYLD 221905 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042355
NM_001042412
NM_015247

NM_001128169
NM_001128170
NM_001128171
NM_001276279
NM_173369

RefSeq (protein)

NP_001035814
NP_001035877
NP_056062
NP_001035814.1
NP_001035877.1

NP_001121642.1
NP_001121643.1
NP_775545.1

Location (UCSC) Chr 16: 50.74 – 50.8 Mb Chr 8: 88.7 – 88.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cylindromatosis (turban tumor syndrome), also known as CYLD, is a human gene.[3]

This gene encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

References[edit]

Further reading[edit]