Triphenylethylene

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Triphenylethylene
Identifiers
  • 1,2-Diphenylethenylbenzene
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.000.359 Edit this at Wikidata
Chemical and physical data
FormulaC20H16
Molar mass256.34104 g/mol g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)C=C(C2=CC=CC=C2)C3=CC=CC=C3

Triphenylethylene (TPE) is a simple aromatic hydrocarbon that possesses weak estrogenic properties.[1][2]

TPE is the parent compound of a group of non-steroidal selective estrogen receptor modulators (SERMs) that includes tamoxifen, clomiphene, chlorotrianisene, DBE, broparestrol, toremifene, droloxifene, idoxifene, ospemifene, fispemifene, and miproxifene, among others.[1][2][3]

TPE and its SERM derivatives were derived from structural modification of diethylstilbestrol.[4]

See also

References

  1. ^ a b JORDAN V. CRAIG; B.J.A. Furr (5 February 2010). Hormone Therapy in Breast and Prostate Cancer. Springer Science & Business Media. pp. 95–. ISBN 978-1-59259-152-7.
  2. ^ a b Philipp Y. Maximov; Russell E. McDaniel; V. Craig Jordan (23 July 2013). Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 4–. ISBN 978-3-0348-0664-0.
  3. ^ Antonio Cano; Joacquim Calaf i Alsina; Jose Luis Duenas-Diez (22 September 2006). Selective Estrogen Receptor Modulators: A New Brand of Multitarget Drugs. Springer Science & Business Media. pp. 52–. ISBN 978-3-540-34742-2.
  4. ^ Carmen Avendano; J. Carlos Menendez (11 June 2015). Medicinal Chemistry of Anticancer Drugs. Elsevier Science. pp. 87–. ISBN 978-0-444-62667-7.



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