Osteocalcin

bone gamma-carboxyglutamate (gla) protein (osteocalcin)
Identifiers
Symbol	BGLAP
NCBI gene	632
HGNC	1043
OMIM	112260
RefSeq	NM_199173
UniProt	P02818
Other data
Locus	Chr. 1 q25-q31
Search for Structures Swiss-model Domains InterPro

Osteocalcin is a noncollagenous protein found in bone and dentin. It is secreted by osteoblasts and thought to play a role in mineralization and calcium ion homeostasis. It has been stipulated that osteocalcin may also function as a negative regulator of bone formation, although its exact role is unknown.

In August 2007, it was reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin.

Use as a biochemical marker for bone formation

As osteocalcin is manufactured by osteoblasts, it is often used as a biochemical marker, or biomarker, for the bone formation process. It has been routinely observed that higher serum-osteocalcin levels are relatively well correlated with increases in bone mineral density (BMD) during treatment with anabolic bone formation drugs for osteoporosis, such as Forteo. In many studies, Osteocalcin is used as a preliminary biomarker on the effectiveness of a given drug on bone formation.

External links

• Osteocalcin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)