Sarcalumenin

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SRL
Identifiers
Aliases SRL, entrez:6345, sarcalumenin
External IDs OMIM: 604992 MGI: 2146620 HomoloGene: 45500 GeneCards: SRL
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098814
NM_001323667
NM_001323668

NM_175347
NM_001347162

RefSeq (protein)

NP_001092284
NP_001310596
NP_001310597

NP_780556.2
NP_001334091
NP_780556

Location (UCSC) Chr 16: 4.19 – 4.24 Mb Chr 16: 4.48 – 4.54 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sarcalumenin is a protein that in humans is encoded by the SAR gene.[3][4]

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.[5] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.[6] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Leberer E, Charuk JH, Green NM, MacLennan DH (August 1989). "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America. 86 (16): 6047–51. doi:10.1073/pnas.86.16.6047. PMC 297772Freely accessible. PMID 2762314. 
  4. ^ Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G (January 1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Research. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137. 
  5. ^ a b Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S (August 2009). "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". American Journal of Physiology. Heart and Circulatory Physiology. 297 (2): H576–82. doi:10.1152/ajpheart.00946.2008. PMC 2724216Freely accessible. PMID 19502553. 
  6. ^ Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H (February 2005). "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". The Journal of Biological Chemistry. 280 (5): 3500–6. doi:10.1074/jbc.M406618200. PMID 15569689. 

External links[edit]