CAMK2G

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CAMK2G
Protein CAMK2G PDB 2ux0.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CAMK2G, CAMK, CAMK-II, CAMKG, calcium/calmodulin dependent protein kinase II gamma
External IDs MGI: 88259 HomoloGene: 15596 GeneCards: CAMK2G
Targeted by Drug
bosutinib[1]
RNA expression pattern
PBB GE CAMK2G 212669 at fs.png

PBB GE CAMK2G 212757 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039138
NM_001039139
NM_178597

RefSeq (protein)
Location (UCSC) Chr 10: 73.81 – 73.87 Mb Chr 14: 20.73 – 20.79 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.[4]

Function[edit]

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.[5]

See also[edit]

Ca2+/calmodulin-dependent protein kinase

Interactions[edit]

CAMK2G has been shown to interact with RRAD.[6]

References[edit]

  1. ^ "Drugs that physically interact with Calcium/calmodulin dependent protein kinase II gamma view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Li X, Nghiem P, Schulman H, Francke U (Feb 1994). "Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14". Cytogenet Cell Genet. 66 (2): 113–6. doi:10.1159/000133679. PMID 8287681. 
  5. ^ "Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma". 
  6. ^ Moyers JS, Bilan PJ, Zhu J, Kahn CR (May 1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.