Pfizer

From Wikipedia, the free encyclopedia
  (Redirected from Pfizer, Inc)
Jump to: navigation, search
"Fizer" redirects here. For the American professional basketball player, see Marcus Fizer.
Pfizer, Inc.
Type Public
Traded as NYSEPFE (component of Dow 30 and S&P 500)
Industry Pharmaceutical
Founded 1849 (1849)
Headquarters New York City, U.S.
Area served Worldwide
Key people Ian Read
(President and CEO)
Products See list
Revenue Decrease US$ 51.584 billion (2013)[1]
Operating income Increase US$ 15.716 billion (2013)[1]
Net income Increase US$ 22.003 billion (2013)[1]
Total assets Decrease US$ 172.101 billion (2013) [1]
Total equity Decrease US$ 76.620 billion (2013)[1]
Employees 78,000 (2013)[2]
Subsidiaries Agouron Pharmaceuticals, G. D. Searle & Company, Greenstone, Parke-Davis, Pfizer UK, Warner Lambert, Wyeth, Zoetis
Website Pfizer.com

Pfizer, Inc. /ˈfzər/ is an American multinational pharmaceutical corporation headquartered in New York City,[3] and with its research headquarters in Groton, Connecticut, United States. It is one of the world's largest pharmaceutical companies by revenues.[4]

Pfizer develops and produces medicines and vaccines for a wide range of medical disciplines, including immunology, oncology, cardiology, diabetology/endocrinology, and neurology. Pfizer's products include the blockbuster drug Lipitor (atorvastatin), used to lower LDL blood cholesterol; Lyrica (pregabalin for neuropathic pain/fibromyalgia); Diflucan (fluconazole), an oral antifungal medication; Zithromax (azithromycin), an antibiotic; Viagra (sildenafil, for erectile dysfunction); and Celebrex/Celebra (celecoxib), an anti-inflammatory drug.

Pfizer was founded by cousins Charles Pfizer and Charles Erhart in New York City in 1849 as a manufacturer of fine chemicals. Pfizer's discovery of Terramycin (oxytetracycline) in 1950 put it on a path towards becoming a research-based pharmaceutical company. Pfizer has made numerous acquisitions, including Warner–Lambert in 2000, Pharmacia in 2003 and Wyeth in 2009. The Wyeth acquisition was the largest of the three at US$68 billion.[5][6] Pfizer is listed on the New York Stock Exchange, and its shares have been a component of the Dow Jones Industrial Average since April 2004.[7]

In September 2009, Pfizer pleaded guilty to the illegal marketing of the arthritis drug Bextra for uses unapproved by the U.S. Food and Drug Administration (FDA), and agreed to a $2.3 billion settlement, the largest health care fraud settlement at that time.[8] Pfizer also paid the U.S. government $1.3 billion in criminal fines related to the "off-label" marketing of Bextra, the largest monetary penalty ever rendered for any crime.[9] Called a repeat offender, this was Pfizer's fourth such settlement with the U.S. Department of Justice in the previous ten years.[10][11]

History[edit]

19th century[edit]

Charles Pfizer

Pfizer is named after German-American cousins Charles Pfizer and Charles Erhart (originally from Ludwigsburg, Germany) who launched a chemicals business, Charles Pfizer and Company, from a building at the intersection of Harrison Avenue and Bartlett Street[12] in Williamsburg, Brooklyn, in 1849. There, they produced an antiparasitic called santonin. This was an immediate success, although it was the production of citric acid that really kick-started Pfizer's growth in the 1880s. Pfizer continued to buy property to expand its lab and factory on the block bounded by Bartlett Street; Harrison Avenue; Gerry Street; and Flushing Avenue. Pfizer's original administrative headquarters was at 81 Maiden Lane in Manhattan.[12]

20th century[edit]

By 1906, sales totaled nearly $3 million.[citation needed]

World War I caused a shortage of calcium citrate that Pfizer imported from Italy for the manufacture of citric acid, and the company began a search for an alternative supply. Pfizer chemists learned of a fungus that ferments sugar to citric acid and were able to commercialize production of citric acid from this source in 1919. As a result Pfizer developed expertise in fermentation technology. These skills were applied to the mass production of the antibiotic penicillin during World War II in response to the need of the U.S. government to treat injured Allied soldiers; most of the penicillin that went ashore with the troops on D-Day was made by Pfizer.[citation needed]

In the 1940s, penicillin became very inexpensive. As a result, Pfizer searched for new antibiotics with greater profit potential. Pfizer's discovery and commercialization of Terramycin (oxytetracycline) in 1950 changed the company from a manufacturer of fine chemicals to a research-based pharmaceutical company. To augment its research in fermentation technology, Pfizer developed a drug discovery program focusing on in vitro synthesis. Pfizer also established an animal health division in 1959 with an 700-acre (2.8 km2) farm and research facility in Terre Haute, Indiana.

By the 1950s, Pfizer had established offices in Belgium, Brazil, Canada, Cuba, Iran, Mexico, Panama, Puerto Rico, Turkey, and the United Kingdom.[citation needed] In 1960, the company moved its medical research laboratory operations out of New York City to a new facility in Groton, Connecticut. In 1980 Pfizer launched Feldene (piroxicam), a prescription anti-inflammatory medication that became Pfizer's first product to reach one billion United States dollars in total sales.[citation needed]

During the 1980s and 1990s, Pfizer Corporation growth was sustained by the discovery and marketing of Zoloft, Lipitor, Norvasc, Zithromax, Aricept, Diflucan, and Viagra.

2000–2010[edit]

Pfizer has recently grown by mergers, including those with Warner–Lambert (2000), Pharmacia (2003), and Wyeth (2009).

On June 26, 2006, Pfizer announced that it would sell its Consumer Healthcare unit (manufacturer of Listerine, Nicorette, Visine, Sudafed and Neosporin) to Johnson & Johnson for $16.6 billion.[13][14][15]

Development of torcetrapib, a drug that increases production of HDL, or "good cholesterol", which reduces LDL thought to be correlated to heart disease, was cancelled in December 2006. During a Phase III clinical trial involving 15,000 patients, more deaths occurred in the group that took the medicine than expected, and a sixty percent increase in mortality was seen among patients taking the combination of torcetrapib and Lipitor versus Lipitor alone. Lipitor alone was not implicated in the results, but Pfizer lost nearly $1 billion developing the failed drug and the market value of the company plummeted in the aftermath.[16][17][18]

A July 2010 article in BusinessWeek reported that Pfizer was seeing more success in its battle against makers of counterfeit prescription drugs by pursuing civil lawsuits rather than criminal prosecution. Pfizer has hired customs and narcotics experts from all over the globe to track down fakes and assemble evidence that can be used to pursue civil suits for trademark infringement. Since 2007, Pfizer has spent $3.3 million on investigations and legal fees and recovered about $5.1 million, with another $5 million tied up in ongoing cases.[19]

On May 6, 2013. Pfizer told The Associated Press that it would begin selling Viagra directly to patients on its website.[20]

Warner–Lambert acquisition[edit]

Pfizer acquired Warner–Lambert in 2000 for $111.8 bn.[21] Warner–Lambert was founded as a Philadelphia drug store in 1856 by William R. Warner. Inventing a tablet-coating process gained Warner a place in the Smithsonian Institution. Parke–Davis was founded in Detroit in 1866 by Hervey Parke and George Davis. Warner–Lambert took over Parke–Davis in 1976 and acquired Wilkinson Sword in 1993 and Agouron in 1999.

Pharmacia acquisition[edit]

In 2002, Pfizer merged with Pharmacia. The merger was again driven in part by the desire to acquire full rights to a product, this time Celebrex (celecoxib), the COX-2 selective inhibitor previously jointly marketed by Searle (acquired by Pharmacia) and Pfizer. In the ensuing years, Pfizer commenced with a massive restructuring resulting in numerous site closures and loss of jobs including: Terre Haute, IN; Holland, MI; Groton, CT; Brooklyn, NY; Sandwich, UK and Puerto Rico.

Pharmacia had been formed by a series of mergers and acquisition with its predecessors, including Searle, Upjohn and Sugen.

Searle was founded in Omaha, Nebraska, in April 1888. The founder was Gideon Daniel Searle. In 1908, the company was incorporated in Chicago. In 1941, the company established headquarters in Skokie, Illinois. It was acquired by the Monsanto Company, headquartered in St. Louis, in 1985.

The Upjohn Company was a pharmaceutical manufacturing firm founded in 1886 in Kalamazoo, Michigan by Dr. William E. Upjohn, an 1875 graduate of the University of Michigan medical school. The company was originally formed to make friable pills, which were specifically designed to be easily digested. In 1995, Upjohn merged with Pharmacia, to form Pharmacia & Upjohn. Pharmacia was created in April 2000 through the merger of Pharmacia & Upjohn with the Monsanto Company and its G.D. Searle unit. The merged company was based in Peapack, New Jersey. The agricultural division was spun off from Pharmacia, as Monsanto, in preparation for the close of the acquisition by Pfizer.[22]

SUGEN was a company focused on protein kinase inhibitors, founded in 1991 in Redwood City, California and acquired by Pharmacia in 1999. The company pioneered the use of ATP-mimetic small molecules to block signal transduction. After the Pfizer merger, the SUGEN site was shut down in 2003, with the loss of over 300 jobs, and the transfer of several programs to Pfizer. These included sunitinib (Sutent), which was approved for human use by the FDA in January 2006, passed $1 bn in annual revenues for Pfizer in 2010.[23] A related compound SU11654 (Toceranib) was also approved for canine tumors, and the ALK inhibitor Crizotinib also grew out of a SUGEN program[24]

In 2008, Pfizer announced 275 job cuts at the Kalamazoo manufacturing facility. Kalamazoo was previously the world headquarters for the Upjohn Company.[25]

Wyeth acquisition[edit]

On January 26, 2009, after more than a year of talks between the two companies, Pfizer agreed to buy pharmaceuticals rival Wyeth for a combined US$68 billion in cash, shares and loans, including some US$22.5 billion lent by five major Wall Street banks. The deal cemented Pfizer's position as the largest pharmaceutical company in the world, with the merged company generating over US$20 billion in cash each year, and was the largest corporate merger since AT&T and BellSouth's US$70 billion deal in March 2006.[26] The combined company was expected to save US$4 billion annually through streamlining; however, as part of the deal, both companies must repatriate billions of dollars in revenue from foreign sources to the United States, which will result in higher tax costs. The acquisition was completed on October 15, 2009, making Wyeth a wholly owned subsidiary of Pfizer.[6]

The merger was broadly criticized. Harvard Business School’s Gary Pisano told The Wall Street Journal that "the record of big mergers and acquisitions in Big Pharma has just not been good. There’s just been an enormous amount of shareholder wealth destroyed".[27] Said analysts at the time, "The Warner–Lambert and Pharmacia mergers do not appear to have achieved gains for shareholders, so it is unclear who benefits from the Wyeth–Pfizer merger to many critics."[28]

King Pharmaceuticals acquisition[edit]

In October 2010, Pfizer agreed to buy King Pharmaceuticals for $3.6 billion in cash or $14.25 per share: an approximately 40% premium over King’s closing share price 11 October 2010.[29]

2011 to present[edit]

In February 2011 it was announced that Pfizer was to close its UK research and development facility (formerly also a manufacturing plant) in Sandwich, Kent, which at that time employed 2,400 people.[30] However, as at 2014 Pfizer retains a reduced presence at the site;[31] it also has a UK research unit at Cambridge.[32]

In April 2011 Pfizer agreed to sell its Capsugel unit, the world's largest maker of hard capsules, for about $2.38 billion to the private equity firm KKR & Co. The cash will be used for a part of share buyback about $5 billion planned for 2011.[33]

In November, 2011, Pfizer acquired Excaliard Pharmaceuticals.[34]

In 2012, Pfizer acquired Alacer Corp., producer of Emergen-C.

On September 4, 2012, the FDA approved a Pfizer pill for a rare type of leukemia. The medicine, called Bosulif, treats chronic myelogenous leukemia (CML), a blood and bone marrow disease that usually affects older adults.[35]

In November, 2012, Pfizer acquired NextWave Pharmaceuticals.[36]

On March 28, 2014, the U.S. Food and Drug Administration approved Pfizer's over-the-counter Nexium® 24HR (esomeprazole 20 mg) for the treatment of frequent heartburn.[37]

In April 2014, it was reported that Pfizer had reignited a $100 billion takeover bid for the UK-based AstraZeneca,[38][39] sparking political controversy in the UK,[40] as well as in the US.[41] On May 19, 2014 a "final offer" of £55 a share was rejected by the AstraZeneca board which said the bid was too low and it imposed too many risks. If successful the takeover, which would have been the biggest in British history, would have made Pfizer the world's largest drug company.[42]

In July 2014, Pfizer announced its acqusition of InnoPharma for up to $360 million.[43]

Zoetis[edit]

Main article: Zoetis

Plans to spin out Zoetis, the Agriculture Division of Pfizer and later Pfizer Animal Health, were announced in 2012. Pfizer filed for registration of a Class A stock with the U.S. Securities and Exchange Commission on August 13, 2012.[44] Zoetis' IPO on February 1, 2013 sold 86.1 million shares for US$ 2.2 billion.[45] Pfizer retained 414 million Class B shares giving it an 83% controlling stake in the firm.[46] The offering's lead underwriters were JPMorgan Chase, Bank of America, Merrill Lynch and Morgan Stanley.[45] Most of the money raised through the IPO was used to pay off existing Pfizer debt.[47]

Operations[edit]

Pfizer world headquarters
The headquarters of Pfizer Japan in Tokyo

Pfizer is organised into nine principal operating divisions: Primary Care, Specialty Care, Oncology, Emerging Markets, Established Products, Consumer Healthcare, Nutrition, Animal Health, and Capsugel.[48]

Research and development[edit]

Pfizer's research and development activities are organised into two principal groups: the PharmaTherapeutics Research & Development Group, which focuses on the discovery of small molecules and related modalities; and the BioTherapeutics Research & Development Group, which focuses on large-molecule research, including vaccines.[48] In 2007, Pfizer invested $8.1 billion in research and development, the largest R&D investment in the pharmaceutical industry.[49]

Pfizer has R&D facilities in the following locations: Groton, Connecticut; La Jolla, California (around 1,000 staff, focused on cancer drugs);[50] South San Francisco, California; Cambridge, Massachusetts; Kalamazoo, Michigan; St. Louis, Missouri; Sandwich, United Kingdom; and Cambridge, United Kingdom.

In 2007, Pfizer announced plans to close or sell on the Loughbeg API facility, located at Loughbeg, Ringaskiddy Co. Cork Ireland by mid to end of 2008. In 2007, Pfizer announced plans to completely close the Ann Arbor, Nagoya and Amboise Research facilities by the end of 2008, eliminating 2,160 jobs and idling the $300-million dollar Michigan facility, which had seen millions of dollars of expansion in recent years.[51]

On June 18, 2007 Pfizer announced that it would move the Animal Health Research (VMRD) division based in Sandwich, England to Kalamazoo, Michigan.[52] On February 1, 2011 Pfizer announced the closure of the Research and Development centre in Sandwich, with the loss of 2,400 jobs.[53] Pfizer subsequently announced that it would maintain a significant presence at Sandwich, with around 650 staff continuing to be based at the site.[54]

On September 1, 2011 Pfizer announced that it had agreed to a 10-year lease of more than 180,000 square feet of research space from MIT in a building to be constructed at 610 Main Street South, just north of the MIT campus in Cambridge, Massachusetts, US. The space will house Pfizer’s Cardiovascular, Metabolic and Endocrine Disease Research Unit and its Neuroscience Research Unit — and Pfizer anticipates moving into the space once it is completed in late 2013.[55]

Products currently[when?] in Pfizer's development pipeline include dimebon and tanezumab.

Senior management[edit]

The members of the board of directors of Pfizer are: Dennis Ausiello, M.D., M. Anthony Burns, W. Don Cornwell, William H. Gray (congressman), Frances D. Fergusson, Helen Hobbs, M.D., Constance Horner, Ian Read (chairman), James M. Kilts, George Lorch, Suzanne Nora Johnson, Stephen Sanger, and Marc Tessier-Lavigne, Ph.D.

Products[edit]

Pharmaceutical products[edit]

Pfizer's pharmaceutical products include:[57]

Xanax (alprazolam) 2 mg tri-score tablets
Bottles of the antidepressant Zoloft

In addition to marketing branded pharmaceuticals, Pfizer is involved in the manufacture and sale of generics. In the US it does this through its Greenstone subsidiary which it acquired as part of the acquisition of Pharmacia.[58] Pfizer also has a licensing deal in place with Aurobindo which grants the former access to a variety of oral solid generic products.[59]

Consumer healthcare products[edit]

ChapStick

Pfizer's consumer healthcare products include:

Promotional practices[edit]

Access to pharmaceutical industry documents has revealed marketing strategies used to promote Neurontin for off-label use.[60] In 1993, the U.S. Food and Drug Administration (FDA) approved gabapentin (Neurontin, Pfizer) only for treatment of seizures. Warner–Lambert, which merged with Pfizer in 2000, used activities not usually associated with sales promotion, including continuing medical education and research, sponsored articles about the drug for the medical literature, and alleged suppression of unfavorable study results, to promote gabapentin. Within 5 years the drug was being widely used for the off-label treatment of pain and psychiatric conditions. Warner–Lambert admitted to charges that it violated FDA regulations by promoting the drug for pain, psychiatric conditions, migraine, and other unapproved uses, and paid $430 million to resolve criminal and civil health care liability charges.[61][62] Today it is a mainstay drug for migraines, even though it was not approved for such use in 2004.[63]

In September 2009, Pfizer agreed to pay $2.3 billion to settle civil and criminal allegations that it had illegally marketed four drugs—Bextra, Geodon, Zyvox, and Lyrica—"for non-approved uses; it was Pfizer's fourth such settlement in a decade.[10][11][64] Pharmacia & Upjohn Company, Inc., a Pfizer subsidiary, agreed to plead guilty to misbranded promotion of Bextra, a felony violation of the Food, Drug and Cosmetic Act. The criminal fine accounts for $1.3 billion of the settlement, and was the largest criminal penalty imposed in American history until the BP plea agreement for the Deepwater Horizon oil spill.[65][66] Pfizer has entered an extensive corporate integrity agreement (CIA) with the Office of Inspector General and will be required to make substantial structural reforms within the company, and maintain the Pfizer website (www.pfizer.com/pmc) to track the company's post marketing commitments. Pfizer must also put a searchable database of all payments to physicians the company has made on the Pfizer website by March 31, 2010.[67] In addition, two former employees were separately indicted and sentenced for their role in marketing of Bextra. A former District Sales manager was found guilty of obstruction of justice for destroying documents pertinent to the investigation, and a Regional Sales Manager pled guilty to the distribution of a misbranded product.[68][69]

The case was also the largest civil settlement against a pharmaceutical company as of then.[70] Pfizer paid a $1 billion civil fine to settle allegations it had illegally promoted the drugs for uses that were not approved by the U.S. Food and Drug Administration (FDA) and caused false claims to be submitted to Federal and State programs including but not limited to Medicare and Medicaid. Under the False Claims Act, damages can be assessed for violations of the federal Anti-Kickback statute, 42 U.S.C. § 1320a–7b(b)[71] and the off-label marketing provision within the Federal Food, Drug, and Cosmetic Act ("FDCA"), 21 U.S.C. §§301-97.[72] Six whistle-blowers will receive $102 million for their participation in the civil investigation, and John Kopchinski, a former sales representative, will receive $51.5 million for his allegations involving the marketing of Bextra.[73]

According to Harper's Magazine publisher John MacArthur, Pfizer withdrew "between $400,000 and a million dollars" worth of ads from their magazine following an unflattering article on depression medication.[74]

Whistleblowers[edit]

Year Image Name Action
1996 David Franklin Exposed illegal promotion of the epilepsy drug Neurontin for un-approved uses while withholding evidence that the drug was not effective for these conditions. Parke-Davis's new owners Pfizer eventually pleaded guilty and paid criminal and civil fines of $430 million. The case had widespread effects including: establishing a new standards for pharmaceutical marketing practices; broadening the use of the False Claims Act to make fraudulent marketing claims criminal violations; exposing complicity and active participation in fraud by renowned physicians; and demonstrating how medical literature had been systematically adulterated by the pharmaceutical industry and its paid clinical consultants. Under the False Claims Act Dr Franklin receives $24.6m as part of the settlement agreement.
2000s Stefan P Kruszewski MD.jpg Stefan P. Kruszewski Kruszewski is a three-time successful whistleblower, with settlements from suits brought against Southwood Psychiatric Hospital, Pfizer, Inc., and AstraZeneca. Kruszewski became aware of inadequate care and the exploiting of state-committed mentally ill children through overmedication and physical and chemical restraints while working for the Department of Public Welfare, Bureau of Program Integrity for the Commonwealth of Pennsylvania. When he refused to keep silent about his discoveries, he was fired from his position at the state.[75] Kruszewski won settlements for both a First Amendment case against the state of Pennsylvania[76] as well as his first Qui tam lawsuit against the hospital.[77] In the cases against pharmaceutical giants, Pfizer[78] and AstraZeneca,[79] Kruszewski highlighted clinical science that was misrepresented by the defendants in their marketing and promotion of certain drugs. He also demonstrated problems with off-label marketing (marketing that promotes uses, patients or doses that are not approved by the US FDA) which resulted in heightened, but often non-transparent, risk to the health of patients and exceptional costs to taxpayers and state and federal governments.[80][81][82][83]
2004 The A2.JPG Peter Rost Former vice president at the pharmaceutical company that reported about accounting irregularities and other irregularities to the US authorities. In response to his whistleblowing he was exiled internally by Pfizer and removed from all responsibilities and decision-making. In 2004, he testified in Congress as a private individual in favour of drug reimportation, a position strongly at odds with the official policy of the pharmaceutical industry. In December 2005, Rost was fired from Pfizer. In September 2006 he published his experiences in the book The Whistleblower: Confessions of a Healthcare Hitman.
2009 John Kopchinski Former Pfizer sales representative and West Point graduate[84] whose whistleblower (“qui tam”) lawsuit launched a massive government investigation into Pfizer’s illegal and dangerous marketing of Bextra, a prescription painkiller. Pfizer paid $1.8 billion to the government to settle the case, including a $1.3 billion criminal fine, which was the largest criminal fine ever imposed for any matter.[85] The Bextra settlement was part of a $2.3 billion global settlement – the largest healthcare fraud settlement in U.S. history.[86]

Litigation[edit]

Pfizer is party to a number of suits stemming from its pharmaceutical products as well as practices of various companies it has acquired or merged with.[10][11][64]

Kelo case[edit]

Pfizer's interest in obtaining property in New London, Connecticut, for expanded facilities led to the Kelo v. New London case before the U.S. Supreme Court.

The Supreme Court's 2005 decision in Kelo v. City of New London handed local governments the right to seize private property for economic development,[87] i.e., offices and a hotel, to enhance Pfizer Inc.'s nearby corporate facility. However, following the completion of the aforementioned Wyeth merger, Pfizer announced it would close its research and development headquarters in New London, Connecticut, moving employees to nearby Groton. The property is now owned and operated by Electric Boat.

Quigley Co.[edit]

Pfizer acquired Quigley in 1968, and the division sold asbestos-containing insulation products until the early 1970s.[88] Asbestos victims and Pfizer have been negotiating a settlement deal which calls for Pfizer to pay $430 million to 80 percent of existing plaintiffs. It will also place an additional $535 million into an asbestos settlement trust that will compensate future plaintiffs as well as the remaining 20 percent of current plaintiffs with claims against Pfizer and Quigley. The compensation deal is worth $965 million all up. Of that $535 million, $405 million is in a 40-year note from Pfizer, while $100 million will come from insurance policies.

Bjork–Shiley heart valve[edit]

Pfizer purchased Shiley in 1979 at the onset of its Convexo-Concave valve ordeal, involving the Bjork–Shiley heart valve. Approximately 500 people died when defective valves failed and, in 1994, the United States ruled against Pfizer for ~$200 million.[89][90]

Abdullahi v. Pfizer, Inc.[edit]

In 1996, an outbreak of measles, cholera, and bacterial meningitis occurred in Nigeria. Pfizer representatives traveled to Kano, Nigeria to administer an experimental antibiotic, trovafloxacin, to approximately 200 children. Local Kano officials report that more than 50 children died in the experiment, while many others developed mental and physical deformities.[91] The nature and frequency of both fatalities and other adverse outcomes were similar to those historically found among pediatric patients treated for meningitis in sub-Saharan Africa.[92] In 2001, families of the children, as well as the governments of Kano and Nigeria, filed lawsuits regarding the treatment.[93] Representing the government is Babatunde Irukera. According to news reports, "[r]esearchers did not obtain signed consent forms, and medical personnel said Pfizer did not tell parents their children were getting the experimental drug."[94] The lawsuits also accuse Pfizer of using the outbreak to perform unapproved human testing, as well as allegedly under-dosing a control group being treated with traditional antibiotics in order to skew the results of the trial in favor of Trovan. Pfizer denied these claims, and subsequently produced an approval letter for testing from the Nigerian Ethics Committee. The Nigerian government insisted that it was a fake and a panel of Nigerian medical experts agreed that the letter had been concocted and backdated by the company's lead researcher in Kano. They went on to conclude that Pfizer never obtained authorization from the Nigerian government to give the unproven drug to children and infants.[95]

In 2007, Pfizer published a Statement of Defense letter.[96] The letter makes several claims, including that Pfizer donated 18 million in Nigerian Naira (NGN) (about $216,000 in 1996 US dollars (USD)),[97] that the drug's oral form was presented as safer and easier to administer, that the administration of Trovan saved lives, and that no unusual side effects, unrelated to meningitis, were observed after 4 weeks.

In June 2010, the US Supreme Court rejected Pfizer's appeal against a ruling allowing lawsuits by the Nigerian families to proceed.[98]

In December 2010, WikiLeaks released US diplomatic cables, which indicate that Pfizer had "used dirty tricks to avoid clinical trial payout". The company had hired investigators to find evidence of corruption against the Nigerian attorney general to persuade him to drop legal action.[99] Washington Post reporter Joe Stephens, who helped break the story in 2000, called these actions "dangerously close to blackmail."[94] In response, the company has released a press statement describing the allegations as "preposterous" and stating that they acted in good faith.[100]

GMO virus[edit]

A scientist claims she was infected by a genetically modified virus while working for Pfizer. In her federal lawsuit she says she has been intermittently paralyzed by the Pfizer-designed virus. "McClain, of Deep River, suspects she was inadvertently exposed, through work by a former Pfizer colleague in 2002 or 2003, to an engineered form of the lentivirus, a virus similar to the one that can lead to acquired immune deficiency syndrome, or AIDS."[101] The court found that McClain failed to demonstrate that her illness was caused by exposure to the lentivirus,[102] but also that Pfizer violated whistleblower laws.[103]

Blue Cross Blue Shield[edit]

Health insurance company Blue Cross Blue Shield (BCBS) filed a lawsuit against Pfizer for reportedly illegally marketing their drugs Bextra, Geodon and Lyrica. BCBS is reporting that Pfizer used "kickbacks" and wrongly persuaded doctors to prescribe the drugs.[104][105] FiercePharma reported that "According to the suit, the drugmaker not only handed out those "misleading" materials on off-label uses, but sent doctors on Caribbean junkets and paid them $2,000 honoraria in return for their listening to lectures about Bextra. More than 5,000 healthcare professionals were entertained at meetings in Bahamas, Virgin Islands and across the U.S., the suit alleges."[106] Pfizer has had similar cases brought against it which it has settled with the US federal government and with more than 40 US states.[107] Pfizer denies the allegations.

Wyeth's Rapamune[edit]

A "whistleblower suit" was filed in 2005 against Wyeth, which was acquired by Pfizer, alleging that the company illegally marketed their drug Rapamune. Wyeth is targeted in the suit for off-label marketing, targeting specific doctors and medical facilities to increased sales of Rapamune, trying to get current transplant patients to change from their current transplant drugs to Rapamune and for specifically targeting African-Americans. According to the whistleblowers, Wyeth also provided doctors and hospitals with kickbacks to prescribe the drug in the form of grants, donations and other money.[108][109] A US House of Representatives committee, led by Rep. Edolphus Towns is currently[when?] investigating these allegations.[110][111]

Brigham Young University[edit]

Controversy arose over the drug "Celebrex." Brigham Young University (BYU) said that a professor of chemistry, Dr. Daniel Simmons, discovered an enzyme in the 1990s which would later lead towards the development of Celebrex. BYU was originally seeking 15% royalty on sales which would equate to $9.7 billion. The court filings show that a research agreement was made with Monsanto, whose pharmaceutical business was later acquired by Pfizer, to develop a better aspirin. The enzyme that Dr. Simmons claims to have discovered would induce pain and inflammation while causing gastrointestinal problems, which Celebrex is used to reduce those issues. A battle ensued, lasting over six years, because BYU claimed that Pfizer did not give him credit or compensation while Pfizer claims it had met all obligations in regards to the Monsanto agreement. This culminated in a $450 million amicable settlement without going to trial. Pfizer said it would take a $450 million charge against first quarter earnings to settle.[112]

Environmental record[edit]

According to the EPA, Pfizer is among the top ten companies in America with the most numerous emissions sources.[113] A landfill and two wastewater lagoons in Ledyard, CT near the Pfizer plant in Groton, Connecticut, are a source of groundwater pollution in the area. According to the Connecticut Department of Environmental Protection (CT DEP), the Pfizer site is active under the CT DEP Site Remediation program.[114] In June 2002, a chemical explosion at the Groton plant injured seven people and caused the evacuation of over 100 homes in the surrounding area.[115]

Pfizer has inherited Wyeth's liabilities in the American Cyanamid site in Bridgewater, New Jersey. This site is highly toxic and an EPA declared Superfund site. Pfizer has since attempted to remediate this land in order to clean and develop it for future profits and potential public uses. Members of the surrounding communities have stated that the EPA has been coerced into accepting a plan that is affordable for Pfizer but is not a complete/proper remediation plan for the site, detrimental to the interest of the community. The EPA has suggested a remediation plan that includes environmental caps and redeveloping a portion of it in the future. This redevelopment will occur on the site which is located within a flood plain, something the EPA failed to address in their feasibility study released in early 2012. The mayor of Bridgewater, the New Jersey Department of Environmental Protection, and other key community leaders also came out to endorse the plan without considering the amount of increased flooding that is going to take place if such a plan is implemented.[116]

Political lobbying[edit]

Pfizer is a leading member of the U.S. Global Leadership Coalition, a Washington D.C.-based coalition of over 400 major companies and NGOs that advocates for a larger International Affairs Budget, which funds American diplomatic, humanitarian, and development efforts abroad.[117]

Pfizer is one of the single largest lobbying interests in United States politics. For example in the first 9 months of 2009 Pfizer spent over $16.3 million on lobbying US congressional lawmakers, making them the sixth largest lobbying interest in the US (following Pharmaceutical Research and Manufacturers of America (PhRMA), which ranked fourth but also represents many of their interests). A spokeswoman for Pfizer said the company “wanted to make sure our voice is heard in this conversation” in regards to the company's expenditure of $25 million in 2010 to lobby health care reform.[118]

Pfizer's primary interests are opposition of Congressional efforts to attach a prescription drug benefit to Medicare and opposition to generic drugs entering US markets.[119] Pfizer also purportedly proposed a ban on all lawsuits against manufacturers of body implant parts which was proposed in the United States Congress as part of tort reform legislation.[120]

According to U.S. State Department cables released by the whistleblower site WikiLeaks, Pfizer "lobbied against New Zealand getting a free trade agreement with the United States because it objected to New Zealand’s restrictive drug buying rules and tried to get rid of New Zealand’s former health minister, Helen Clark, in 1990.[121][122]

Employment and diversity[edit]

Pfizer received a 100% rating on the Corporate Equality Index released by the Human Rights Campaign starting in 2004, the third year of the report. In 2007, Pfizer's Canadian division was named one of Canada's Top 100 Employers, as published in Maclean's magazine, the only research-based pharmaceutical company to receive this honor.[123] In 2008, there was controversy, including inquiries from members of Congress, around Pfizer's practice of replacing US workers with H-1b guest workers[124]

AIDS involvement[edit]

Pfizer has been involved in controversies over the medicine Diflucan (generic name fluconazole). In 1998, a campaign by Thai public health groups led to the elimination of the Pfizer monopoly on selling fluconazole in Thailand, and the price of the antifungal drug decreased from 200 baht to 6.5 baht in nine months, vastly expanding access to the medicine for AIDS patients. Faced with pressure for compulsory licenses to the Pfizer patent on this drug, Pfizer later established a program for limited access to the medicine in Africa.[125]

"In the United States, 46 percent of all new HIV/AIDS cases occur in the South. From 2003 to 2006 the Pfizer Foundation has funded 23 innovative HIV/AIDS prevention programs and strengthened the capacity of community-based organizations to reach and serve their communities."[126] Since 2003, Pfizer has committed a $3 million grant toward supporting the Southern HIV/AIDS Prevention Initiative.

However, there were criticisms of the way Pfizer was testing its AIDS drug. "The European AIDS Treatment Group (EATG), collection of activists from 31 European Countries,[127] said the design of the trial for Pfizer's CCR5 inhibitor maraviroc (previously known as UK-427,857) is putting people with HIV infection at unnecessary risk of developing AIDS."[128]

On June 20, 2007, Pfizer received an approvable letter for maraviroc from the FDA advisory board. The letter was a product of expedited review of the novel HIV compound.[129]

In 2001, Pfizer asked the U.S. government to pressure the Brazilian government against issuing compulsory licenses for the patents on the AIDS drug nelfinavir.[citation needed]

In November 2009 Pfizer formed a joint venture with GlaxoSmithKline to create ViiV Healthcare. Viiv Healthcare received all of Pfizer and GlaxoSmithKline's HIV assets.[130]

AIDS drugs previously manufactured by Pfizer which are now produced by ViiV Healthcare include Viracept (nelfinavir mesylate), Selzentry/Celsentri (maraviroc) and Rescriptor (delavirdine mesylate).

See also[edit]

References[edit]

  1. ^ a b c d e "PFIZER INC 2013 Annual Report Form (10-K)" (XBRL). United States Securities and Exchange Commission. February 28, 2014. 
  2. ^ "Pfizer 2013 Annual Review". Pfizer. 
  3. ^ "Contact Us." Pfizer. Retrieved on April 3, 2010.
  4. ^ "Pfizer moves higher amid persistent breakup talk". Bloomberg Businessweek. 27 March 2012. Retrieved 8 July 2012. 
  5. ^ Andrew Ross Sorkin and Duff Wilson (January 26, 2009). "Pfizer Agrees to Pay $68 billion for Rival Drug Maker Wyeth". The New York Times. 
  6. ^ a b "Wyeth Transaction". Pfizer. Retrieved October 25, 2009. 
  7. ^ Dow Jones Industrial Average Historical Components from moneycontrol.com
  8. ^ "Pfizer pays $2.3 billion to settle marketing case", The New York Times, September 2, 2009.
  9. ^ "Bextra whistleblower case leads to record-setting settlement", Phillips & Cohen Press Release, September 2, 2009.
  10. ^ a b c Harris, Gardiner (September 3, 2009). "Pfizer Pays $2.3 billion to Settle Marketing Case". The New York Times. 
  11. ^ a b c Johnson, Carrie (September 3, 2009). "In Settlement, A Warning To Drugmakers: Pfizer to Pay Record Penalty In Improper-Marketing Case". The Washington Post. 
  12. ^ a b Kenneth T. Jackson. [yalepress.yale.edu/yupbooks/book.asp?isbn= 9780300055368 The Encyclopedia of New York City]. The New York Historical Society; Yale University Press; September 1995. P. 895. ISBN 978-0-300-05536-8
  13. ^ "Johnson & Johnson to Buy Pfizer Unit". MoneyNews.com. June 26, 2006. Retrieved July 19, 2007. [dead link]
  14. ^ "Johnson & Johnson Completes Acquisition Of Pfizer Consumer Healthcare" (Press release). Johnson & Johnson. December 20, 2006. 
  15. ^ Saul, Stephanie (June 27, 2006). "Johnson & Johnson Buys Pfizer Unit for $16.6 billion". The New York Times. 
  16. ^ Pfizer Shares Plummet on Loss of a Promising Heart Drug By ALEX BERENSON and ANDREW POLLACK. December 5, 2006. The New York Times
  17. ^ Berenson, Alex (December 3, 2006). "Pfizer Ends Studies on Drug for Heart Disease". The New York Times. Retrieved December 3, 2006. 
  18. ^ Theresa Agovino (Associated Press) (December 3, 2006). "Pfizer ends cholesterol drug development". Yahoo! News. Retrieved December 3, 2006. [dead link] Each study arm (torcetrapib + Lipitor vs. Lipitor alone) had 7500 patients enrolled; 51 deaths were observed in the Lipitor alone arm, while 82 deaths occurred in the torcetrapib + Lipitor arm.
  19. ^ Bennett, Simeon (July 8, 2010). "Pfizer: Civil Suits for Drug Counterfeiters". BusinessWeek. Retrieved July 11, 2011. 
  20. ^ "Pfizer to sell Viagra online, in first for Big Pharma: AP". CBS News. Retrieved 6 May 2013. 
  21. ^ Pfizer, 2000: Pfizer joins forces with Warner–Lambert, accessed April 7, 2010
  22. ^ "Pharmacia to Spin Off Monsanto Stake, Less Than 2 Years After Firms' Merger Wall Street Journal 28nov01". 
  23. ^ "Pfizer 2010 annual financial review, p 25." (PDF). Retrieved July 11, 2011. 
  24. ^ "Pfizer Drug Targets Gene Flaw to Shrink Lung Tumors (Update1)". Businessweek. Retrieved July 11, 2011. 
  25. ^ "Pfizer plant in Michigan to cut 275 – FiercePharma". 
  26. ^ Pfizer Agrees to Pay $68 billion for Rival Drug Maker Wyeth By ANDREW ROSS SORKIN and DUFF WILSON. January 26, 2009. The New York Times
  27. ^ The Pfizer–Wyeth Deal Worst-Case Scenario By Jim Edwards | January 23, 2009 – BNET
  28. ^ Matthew Karnitschnig, & Jonathan D. Rockoff. (2009, January 23). Pfizer in Talks to Buy Wyeth. Wall Street Journal (Eastern Edition), p. A.1. Retrieved March 7, 2010, from Wall Street Journal. (Document ID: 1631280041).
  29. ^ "Pfizer to buy King Pharma for $3.6 billion in cash". Reuters. October 12, 2010. Retrieved October 12, 2010. 
  30. ^ "Pfizer to close UK research site". BBC News. February 1, 2011. 
  31. ^ Pfizer R&D Locations: Sandwich, UK
  32. ^ Pfizer R&D Locations: Cambridge, UK
  33. ^ Pfizer selling Capsugel to KKR for $2.38 billion http://www.newsdaily.com/stories/tre73321d-us-pfizer-kkr/
  34. ^ http://www.pfizer.com/news/press-release/press-release-archive-detail/pfizer_to_acquire_excaliard_pharmaceuticals
  35. ^ "FDA approves Pfizer leukemia drug". Reuters. Retrieved 4 September 2012. 
  36. ^ http://www.pfizer.com/news/press-release/press-release-archive-detail/pfizer_acquires_nextwave_pharmaceuticals_inc
  37. ^ [1]
  38. ^ Ben Hirschler (28 April 2014). "Pfizer chases AstraZeneca for potential $100 billion deal". Reuters. 
  39. ^ Brozak, Steve. "No Longer King Of The North, Pfizer Looks To Recapture Crown". Forbes. Retrieved 30 April 2014. 
  40. ^ Cameron and Miliband clash over Pfizer deal, BBC News, May 7, 2014.
  41. ^ US politicians raise questions over Pfizer bid, BBC News, May 9, 2014.
  42. ^ "AstraZeneca rejects Pfizer 'final' takeover offer, triggers major drop in shares". London Mercury. Retrieved May 20, 2014. 
  43. ^ http://www.genengnews.com/gen-news-highlights/pfizer-to-acquire-innopharma-for-up-to-360m/81250112/
  44. ^ "Zoetis™ Files IPO Registration Statement". Bloomberg L.P. New York. August 13, 2012. Retrieved 1 February 2013. 
  45. ^ a b J. DE LA MERCED, MICHAEL (February 1, 2013). "Shares of Zoetis Surge on Debut". New York Times (New York). Retrieved 1 February 2013. 
  46. ^ DIETERICH, CHRIS (January 31, 2013). "Zoetis Raises $2.2 Billion in IPO - WSJ.com". The Wall Street Journal (New York). Retrieved 1 February 2013. 
  47. ^ "Shares of animal health company Zoetis soar in IPO". CBS News (New York). February 1, 2013. Retrieved 1 February 2013. 
  48. ^ a b "Pfizer Leadership and Structure". Pfizer. Retrieved 6 January 2013. 
  49. ^ "Annual Review 2007 | Pfizer: the world's largest research-based pharmaceutical company". Pfizer. October 9, 2009. Retrieved July 11, 2011. 
  50. ^ Pollack, Andrew (September 2, 2009). "For Profit, Industry Seeks Cancer Drugs". The New York Times. Retrieved September 3, 2009. 
  51. ^ Pfizer's cuts blindside Ann Arbor workers, Kalamazoo Gazette, Sunday, January 23, 2007.
  52. ^ Pfizer Reorganization Could Bring Jobs To Kalamazoo, WWMT.com, June 18, 2007
  53. ^ "Drug giant Pfizer to pull out of Kent". Kentonline.co.uk. February 1, 2011. Retrieved July 11, 2011. 
  54. ^ "Pfizer site in Sandwich set to retain 650 jobs". BBC News. 4 November 2011. Retrieved 9 July 2012. 
  55. ^ "Pfizer Expands its Research Footprint in Cambridge". MITnews. September 1, 2011. 
  56. ^ "Pfizer's Jeffrey Kindler resigns as chief executive". BBC News. December 6, 2010. Retrieved December 6, 2010. 
  57. ^ "Pfizer Prescription Products". Pfizer Inc. Retrieved March 9, 2010. 
  58. ^ Hollis, Liz "Greenstone – Top 10 Generic Drug Companies 2010" Fierce Pharma, August 10, 2010
  59. ^ "Greenstone press releases" Greenstone corporate website, Retrieved November 3, 2010
  60. ^ Steinman MA, Bero LA, Chren MM, Landefeld CS (August 2006). "Narrative review: the promotion of gabapentin: an analysis of internal industry documents". Ann. Intern. Med. 145 (4): 284–93. doi:10.7326/0003-4819-145-4-200608150-00008. PMID 16908919. Retrieved December 2, 2009. 
  61. ^ The settlement was the first off-label promotion case successfully brought under the False Claims Act. Henney JE (August 2006). "Safeguarding patient welfare: who's in charge?". Ann. Intern. Med. 145 (4): 305–7. doi:10.7326/0003-4819-145-4-200608150-00013. PMID 16908923. Retrieved December 2, 2009. 
  62. ^ "Warner–Lambert to pay $430 million to resolve criminal & civil health care liability relating to off-label promotion" (Press release). US Department of Justice. May 13, 2004. Retrieved December 2, 2009. 
  63. ^ Mathew NT, Rapoport A, Saper J, et al. (February 2001). "Efficacy of gabapentin in migraine prophylaxis". Headache 41 (2): 119–28. doi:10.1046/j.1526-4610.2001.111006119.x. PMID 11251695. 
  64. ^ a b "Pfizer agrees record fraud fine". BBC. September 2, 2009. Retrieved May 22, 2010. 
  65. ^ The United States Department of Justice – United States Attorney's Office – District of Massachusetts[dead link]
  66. ^ The United States Department of Justice – Office of Public Affairs - BP Exploration and Production Inc. Agrees to Plead Guilty to Felony Manslaughter, Environmental Crimes and Obstruction of Congress Surrounding Deepwater Horizon Incident.
  67. ^ http://oig.hhs.gov/fraud/cia/agreements/pfizer_inc.pdf
  68. ^ The United States Department of Justice – United States Attorney's Office – District of Massachusetts[dead link]
  69. ^ The United States Department of Justice – United States Attorney's Office – District of Massachusetts[dead link]
  70. ^ [2][dead link]
  71. ^ "Compliance Readiness – Law Firms The False Claims Act & The Anti-Kickback Act – A Potent Combination Against The Health Care Industry And Growing Even Stronger?" article by Shannon S. Quill, Ballard Spahr Andrews & Ingersoll, LLP, October 1, 2006 on metrocorpcounsel.com, accessed February 3, 2009
  72. ^ "Pfizer whistleblower case – news stories, Bextra lawsuit". Phillipsandcohen.com. Retrieved July 11, 2011. 
  73. ^ "Pfizer settlement – lawyers for Bextra whistleblower's off-label case". Phillipsandcohen.com. Retrieved July 11, 2011. 
  74. ^ Petrovich, Dushko (March 15, 2013). "The Art of Making Magazines edited by Victor S. Navasky and Evan Cornog". Bookforum. Retrieved 2013-03-18. 
  75. ^ Stefan P. Kruszewski v Pfizer Inc., et al. No. 04-1420 (United States District Court for the Middle District of Pennsylvania
  76. ^ Stefan P. Kruszewski v Pfizer Inc., et al. Settlement Agreement. No. 04-1420 (United States District Court for the Middle District of Pennsylvania
  77. ^ United States of America ex rel. Stefan P. Kruszewski v Southwood Psychiatric Hospital; and Youth and Family Centered Services, Inc. a/k/a YFCS, Inc. Civil Action No. 05-1839 (Eastern District Pennsylvania)
  78. ^ United States et al. ex rel. Stefan Kruszewski v. Pfizer, Inc., Civ. No. 07-4106 (Eastern District Pennsylvania)
  79. ^ United States of America ex rel. Stefan Kruszewski v. AstraZeneca Pharmaceuticals LP, Civil Action No. 06-4004 (Eastern District Pennsylvania)
  80. ^ Woolner, Ann. AIG of Drugmakers Pfizer is Too Big to Be Guilty [Online]. Bloomberg, L.P. 3 Sept 2009. Available at: http://www.bloomberg.com/apps/news?pid=newsarchive&sid=ahodmf54hyPA#
  81. ^ Howard, Lee. Lawsuit hits credibility of Pfizer drug and research [Online]. The Day Publishing Company. 4 Oct 2009. Available at: http://www.theday.com/article/20091004/BIZ02/310049957
  82. ^ Drug Discovery and Development. Pfizer Pays $2 Billion to Settle Off-Label Marketing Case [Online]. Ddmag.com. 2 Sept 2009. Available at: http://www.dddmag.com/news-Pfizer-Pays-2-Billion-to-Settle-Off-Label-Marketing-Case-090209.aspx
  83. ^ Deming, Tavy and Brian Kenney. AstraZeneca Pays $520 Million to Settle Seroquel Whistleblower Claims [Online]. PRWeb. 28 Apr 2010[Accessed 17 Jul 2011]. Available at: http://www.prweb.com/releases/2010/04/prweb3937374.htm
  84. ^ Shannon Green (2010-10-04). "Qui tam case looked like a winner – and was it ever". The National Law Journal. 
  85. ^ U.S. Department of Health and Human Services (2009-09-02). "Justice Department Announces Largest Health Care Fraud Settlement in its History". HHS.gov. 
  86. ^ Rita Rubin (2009-09-03). "Pfizer fined $2.3 billion for illegal marketing in off-label drug case". USA Today. 
  87. ^ [3] Kelo v. New London: Opinion of the Court
  88. ^ [4] Quigley Company reorganization
  89. ^ Blackstone, E.H., 2005. Could It Happen Again?: The Bjork–Shiley Convexo-Concave Heart Valve Story" Circulation 111(21), 2717–2719.[5]
  90. ^ Bloomfield, P. et al., 1991. Twelve-year comparison of a Bjork–Shiley mechanical heart valve with porcine bioprostheses" N Engl J Med 324(9), 573–579.
  91. ^ Murray, Senan (June 20, 2007). "Africa | Anger at deadly Nigerian drug trials". BBC News. Retrieved July 11, 2011. 
  92. ^ Ramakrishnan M, Ulland AJ, Steinhardt LC, Moïsi JC, Were F, Levine OS (2009). "Sequelae due to bacterial meningitis among African children: a systematic literature review". BMC Med 7: 47. doi:10.1186/1741-7015-7-47. PMC 2759956. PMID 19751516. 
  93. ^ "Nigerians sue Pfizer over test deaths". BBC News. August 30, 2001. Retrieved May 22, 2010. 
  94. ^ a b WikiLeaks Cables: Pfizer Targeted Nigerian Attorney General to Undermine Suit over Fatal Drug Tests, Democracy Now!
  95. ^ Panel Faults Pfizer in '96 Clinical Trial In Nigeria. The Washington Post. May 7, 2006
  96. ^ "Trovan, Kano State Civil Case – Statement Of Defense" (PDF). Retrieved July 11, 2011. 
  97. ^ "FXHistory – Historical Currency Exchange Rates". Oanda.com. April 16, 2011. Retrieved July 11, 2011. 
  98. ^ "Pfizer-Nigeria appeal dismissed". BBC News. June 29, 2010. 
  99. ^ Boseley, Sarah (December 9, 2010). "WikiLeaks cables: Pfizer 'used dirty tricks to avoid clinical trial payout'". The Guardian (London). 
  100. ^ "Press Statement Regarding Article in The Guardian" (PDF). Pfizer. December 9, 2010. Retrieved December 13, 2010. 
  101. ^ "Ex-Pfizer Worker Cites Genetically Engineered Virus In Lawsuit Over Firing". Courant.com. March 14, 2010. Retrieved July 11, 2011. 
  102. ^ "McClain v. PFIZER, INC., 692 F. Supp. 2d 229". Retrieved September 13, 2012. 
  103. ^ "A Pfizer Whistle-Blower Is Awarded $1.4 Million". The New York Times. April 2, 2010. Retrieved September 13, 2012. 
  104. ^ "Blue Cross Names and Shames Pfizer Execs Linked to Massages-for-Prescriptions Push | BNET". Industry.bnet.com. June 10, 2010. Retrieved July 11, 2011. 
  105. ^ Bounds, Jeff (June 10, 2010). "Blue Cross Blue Shield of Texas sues Pfizer". 
  106. ^ Tracy Staton (June 11, 2010). "BCBS names Pfizer managers in kickback suit". FiercePharma. Retrieved July 11, 2011. 
  107. ^ "Blue Cross Blue Shield of Texas sues Pfizer over drug marketing | News for Dallas, Texas | Dallas Morning News | Dallas Business News". Dallasnews.com. June 11, 2010. Retrieved July 11, 2011. 
  108. ^ "Wyeth Marketing Targeted Blacks Illegally: Lawsuit // Pharmalot". Pharmalot.com. May 24, 2010. Retrieved July 11, 2011. 
  109. ^ Tracy Staton (June 14, 2010). "Congress joins probe into Wyeth's Rapamune marketing". FiercePharma. Retrieved July 11, 2011. 
  110. ^ Richwine, Lisa (June 11, 2010). "UPDATE 1-U.S. panel probes marketing of Wyeth transplant drug". Reuters. 
  111. ^ "U.S. Lawmakers to Investigate Wyeth Illegal Marketing (Update2)". BusinessWeek. Retrieved July 11, 2011. 
  112. ^ http://www.ajc.com/health/pfizer-settles-lawsuit-involving-1429314.html
  113. ^ "What's Happening at KLD". Kld.com. Retrieved July 11, 2011. 
  114. ^ "Find New England Sites – PFIZER, INC". Yosemite.epa.gov. May 17, 2007. Retrieved July 11, 2011. 
  115. ^ The tempest. The Washington Post. May 28, 2006
  116. ^ "Even after costly clean-up, toxins would remain at American Cyanamid site". My Central Jersey. Retrieved March 21, 2012. 
  117. ^ "U.S. Global Leadership Coalition, Global Trust members". Usglc.org. Retrieved July 11, 2011. 
  118. ^ Steinbrook, R., 2009. Lobbying, Campaign Contributions, and Health Care Reform" New England Journal of Medicine 361(23), e52–e52. [6]
  119. ^ [7] Heavy Hitters Pfizer Inc.
  120. ^ [8] Justice, Texas-Style
  121. ^ WikiLeaks: Pfizer Opposed New Zealand Trade Deal, Democracy Now! (December 20, 2010)
  122. ^ David Fisher and Jonathan Milne (December 19, 2010). "WikiLeaks: Drug firms tried to ditch Clark". The New Zealand Herald. Retrieved November 3, 2011. 
  123. ^ "Reasons for Selection, 2007 Canada's Top 100 Employers". 
  124. ^ "Pfizer's American Workers Training Their Replacements". 
  125. ^ Sithole, Emelia (February 21, 2001). "S.Africa okays Pfizer AIDS drug distribution". Reuters NewMedia. Retrieved May 15, 2006. 
  126. ^ "Global HIV/AIDS Partnerships: Southern HIV/AIDS Prevention Initiative". Pfizer. Retrieved May 15, 2006. 
  127. ^ "European AIDS Treatment Group". Retrieved May 15, 2006. 
  128. ^ Hirschler, Ben (April 12, 2005). "Activists attack ethics of Pfizer AIDS drug trial". AIDS Meds.com. Archived from the original on April 26, 2006. Retrieved May 15, 2006. 
  129. ^ "Maraviroc receives accelerated approval in US". Aidsmap.com. Retrieved July 11, 2011. 
  130. ^ "/ Companies / Pharmaceuticals – GSK and Pfizer to merge HIV portfolios". Financial Times. April 16, 2009. Retrieved July 11, 2011.