SYT9

SYT9
Identifiers
Aliases	SYT9, synaptotagmin 9
External IDs	OMIM: 613528; MGI: 1926373; HomoloGene: 11062; GeneCards: SYT9; OMA:SYT9 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	7,469,043 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	107,147,863 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; cerebellar vermis; ; corpus callosum; ; lateral nuclear group of thalamus; ; subthalamic nucleus; ; cerebellar hemisphere; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; ventral tegmental area; ; pars reticulata;
	Top expressed in
	habenula; ; medial dorsal nucleus; ; lumbar spinal ganglion; ; medial geniculate nucleus; ; molar; ; Epithelium of choroid plexus; ; lateral geniculate nucleus; ; lobe of cerebellum; ; cerebellar vermis; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-dependent phospholipid binding; metal ion binding; clathrin binding; calcium ion binding; syntaxin binding; identical protein binding; phosphatidylserine binding; phosphatidylinositol-4,5-bisphosphate binding; SNARE binding;
Cellular component	cytoplasmic vesicle; integral component of membrane; cell junction; synapse; dense core granule; synaptic vesicle membrane; secretory granule membrane; membrane; secretory granule; plasma membrane; clathrin-coated vesicle membrane; integral component of synaptic vesicle membrane; hippocampal mossy fiber to CA3 synapse; exocytic vesicle;
Biological process	regulation of insulin secretion; positive regulation of calcium ion-dependent exocytosis; regulation of calcium ion-dependent exocytosis; vesicle fusion; calcium ion-regulated exocytosis of neurotransmitter; membrane organization; calcium-dependent activation of synaptic vesicle fusion; regulation of dopamine secretion; synaptic vesicle exocytosis; vesicle-mediated transport; calcium-ion regulated exocytosis; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
	143425
	60510
	ENSG00000170743
	ENSMUSG00000062542
	Q86SS6
	Q9R0N9
	NM_175733
	NM_021889
	NP_783860
	NP_068689
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.^[5]^[6]

Interactions

SYT9 has been shown to interact with SYNCRIP,^[7] TUBB^[8] and TRPV1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170743 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062542 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
^ "Entrez Gene: SYT9 synaptotagmin IX".
^ Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
^ Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.
^ Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.
Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

\* Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.

Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron. 34 (4): 599–611. doi:10.1016/S0896-6273(02)00671-2. PMID 12062043. S2CID 16768299.
Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K (Feb 2002). "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells". The Journal of Biological Chemistry. 277 (7): 4601–4. doi:10.1074/jbc.C100588200. PMID 11751925.
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Perin MS (Oct 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170743 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11543631-5] Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.

[entrez-6] "Entrez Gene: SYT9 synaptotagmin IX".

[pmid10734137-7] Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

[pmid12966166-8] Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

[pmid15066994-9] Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.

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Interactions

References

Further reading