3',5'-cyclic-AMP phosphodiesterase

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3',5'-cyclic-AMP phosphodiesterase
Identifiers
EC number 3.1.4.53
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3',5'-cyclic-AMP 5'-nucleotidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

adenosine 3',5'-cyclic phosphate + H2O AMP

This enzyme requires Mg2+ or Mn2+ for activity.

References[edit]

  1. ^ Alonso, G.D.; Schoijet, A.C.; Torres, H.N.; Flawiá, M.M. (2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Mol. Biochem. Parasitol. 145 (1): 40–49. PMID 16225937. doi:10.1016/j.molbiopara.2005.09.005. 
  2. ^ Bader, S.; Kortholt, A.; Snippe, H.; Van Haastert, P.J. (2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". J. Biol. Chem. 281 (29): 20018–20026. PMID 16644729. doi:10.1074/jbc.M600040200. 
  3. ^ Rascón, A.; Soderling, S.H.; Schaefer, J.B.; Beavo, J.A. (2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proc. Natl. Acad. Sci. USA. 99 (7): 4714–4719. PMC 123713Freely accessible. PMID 11930017. doi:10.1073/pnas.002031599. 
  4. ^ Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiol. 6: #25–25. PMC 1431542Freely accessible. PMID 16522215. doi:10.1186/1471-2180-6-25. 
  5. ^ Lugnier, C.; Keravis, T.; Le Bec, A.; Pauvert, O.; Proteau, S.; Rousseau, E. (1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta. 1472 (3): 431–446. PMID 10564757. doi:10.1016/S0304-4165(99)00145-2. 
  6. ^ Imamura, R.; Yamanaka, K.; Ogura, T.; Hiraga, S.; Fujita, N.; Ishihama, A.; Niki, H. (1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. Chem. 271 (41): 25423–25429. PMID 8810311. doi:10.1074/jbc.271.41.25423. 

External links[edit]