8-Chlorotheophylline
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| Routes of administration | Oral |
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| ECHA InfoCard | 100.001.446 |
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| Formula | C7H7ClN4O2 |
| Molar mass | 214.61 g·mol−1 |
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8-Chlorotheophylline, also known as 1,3-dimethyl-8-chloroxanthine, is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine.[1] Its main use is in combination (salt) with diphenhydramine in the antiemetic dimenhydrinate. Diphenhydramine reduces nausea but causes drowsiness, and the stimulant properties of 8-Chlorotheophylline help ward off that side-effect.
Despite being classified as a xanthine stimulant, 8-Chlorotheophylline can generally not produce any locomotor activity above control in mice and does not appear to cross the blood-brain barrier well.
References
- ^ Snyder SH, Katims JJ, Annau Z, Bruns RF, Daly JW (May 1981). "Adenosine receptors and behavioral actions of methylxanthines". Proceedings of the National Academy of Sciences of the United States of America. 78 (5): 3260–4. Bibcode:1981PNAS...78.3260S. doi:10.1073/pnas.78.5.3260. PMC 319541. PMID 6265942.
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