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Sturamustine

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Sturamustine
Clinical data
Other namesN-(2-Chloroethyl)-N'-(3-hydroxyandrost-5-en-17-yl)-N-nitrosourea
Identifiers
  • N-(2-Chloroethyl)-N'-[(3β,17β)-3-hydroxyandrost-5-en-17-yl]-N-nitrosocarbamimidic acid
CAS Number
ChemSpider
Chemical and physical data
FormulaC22H34ClN3O3
Molar mass423.982 g/mol g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2/N=C(/N(CCCl)N=O)\O)CC=C4[C@@]3(CC[C@@H](C4)O)C
  • InChI=1S/C22H34ClN3O3/c1-21-9-7-15(27)13-14(21)3-4-16-17-5-6-19(22(17,2)10-8-18(16)21)24-20(28)26(25-29)12-11-23/h3,15-19,27H,4-13H2,1-2H3,(H,24,28)/t15-,16-,17-,18-,19-,21-,22-/m0/s1
  • Key:QSHCCJGNLACWQQ-UMWWKMARSA-N

Sturamustine, also known as dehydroepiandrosterone (DHEA) 17β-N-(2-chloroethyl)-N-nitrosourea, is a synthetic androstane steroid and a C17β nitrosourea conjugate of dehydroepiandrosterone (DHEA) that was developed as an alkylating antineoplastic agent (i.e., a chemotherapy drug) for the treatment of hormone-dependent tumors but was never marketed.[1][2] It was synthesized in 1982.[1][2]

See also

References

  1. ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 1122. ISBN 978-1-4757-2085-3.
  2. ^ a b Chavis C, de Gourcy C, Borgna JL, Imbach JL (1982). "New steroidal nitrosoureas". Steroids. 39 (2): 129–47. PMID 7071885.


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