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Thiethylperazine

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Thiethylperazine
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Pharmacokinetic data
Protein binding60%
Identifiers
  • 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.014.381 Edit this at Wikidata
Chemical and physical data
FormulaC22H29N3S2
Molar mass399.618 g/mol g·mol−1
3D model (JSmol)
  • S(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CC
  • InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 checkY
  • Key:XCTYLCDETUVOIP-UHFFFAOYSA-N checkY
  (verify)

Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.

Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.[1]

References

  1. ^ Science Daily (September 1, 2011). "Alzheimer Disease: Transport Protein ABCC1 Plays Key Role in Clearing Beta-Amyloid from Brains of Mice". Retrieved September 1, 2011.
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