AM-855

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AM-855
AM-855.svg
Systematic (IUPAC) name
(4aR,12bR)-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho[3,2-c]isochromen-12-ol
Clinical data
Legal status
?
Identifiers
ATC code ?
PubChem CID 10091328
ChemSpider 8266865 YesY
ChEMBL CHEMBL303479 YesY
Chemical data
Formula C26H38O2 
Mol. mass 382.577 g/mol
 YesY (what is this?)  (verify)

AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8Tetrahydrocannabinol with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3nM at CB1 and 58.6nM at CB2.[1]

References[edit]

  1. ^ Khanolkara, Atmaram D.; Dai Lua, Pusheng Fana, Xiaoyu Tiana and Alexandros Makriyannis (August 1999). "Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol". Bioorganic & Medicinal Chemistry Letters 9 (15): 2119–24. doi:10.1016/S0960-894X(99)00355-8. PMID 10465529.