Arachidonylcyclopropylamide

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Arachidonylcyclopropylamide
Arachidonylcyclopropylamide.svg
Names
IUPAC name
N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Other names
ACPA
Identifiers
229021-64-1 N
ChEMBL ChEMBL418353 YesY
ChemSpider 4470548 YesY
Jmol-3D images Image
PubChem 5311007
Properties
C23H37NO
Molar mass 343.55 g·mol−1
Solubility in other solvents soluble in ethanol, chloroform, THF and DMSO
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N
Infobox references

Arachidonylcyclopropylamide (ACPA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 2.2 nM for CB1R; Ki = 700 nM for CB2R).[1]

References[edit]

  1. ^ Hillard, CJ et al. (1999). "Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)". The Journal of Pharmacology and Experimental Therapeutics 289 (3): 1427–33. PMID 10336536.