JWH-073

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JWH-073
JWH073.svg
Systematic (IUPAC) name
naphthalen-1-yl-(1-butylindol-3-yl)methanone
Clinical data
Legal status
  • Schedule I US, Illegal in Latvia[1] & Poland
Identifiers
CAS number 208987-48-8 YesY
ATC code ?
PubChem CID 10471670
ChemSpider 8647081
Chemical data
Formula C23H21NO 
Mol. mass 327.42 g/mol
 YesY (what is this?)  (verify)

JWH-073 is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5x the affinity at CB2.[2] The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.

On 20 April 2009, JWH-073 was claimed by researchers at the University of Freiburg to have been found in a "fertiliser" product called "Forest Humus", along with another synthetic cannabinoid (C8)-CP 47,497.[3] These claims were confirmed in July 2009 when tests of Spice product, seized after the legal ban on JWH-018 had gone into effect in Germany, were shown to contain the unregulated compound JWH-073 instead.[4]

Pharmacology[edit]

JWH-073 has been shown to produce behavioral effects very similar to THC in animals.[5]

Its effects are produced by binding and acting as an agonist to the CB1 and CB2 cannabinoid receptors. The CB1 receptor is found in the brain. JWH-073 bind to CB1 with a higher affinity than THC, suggesting that taking more too soon after the initial dose could lead to diminished effects.[dubious ] CB2 is found outside the brain, mostly in the immune system. The binding with CB2 receptors has been shown to be similar between JWH-073 and THC.[5]

A search in the literature yielded no published studies of the effects of JWH-073 in humans, but these studies in animals suggest with high probability that JWH-073 produces effects very similar to those of THC in humans.[5]

Derivatives[edit]

The 4'-methyl derivative of JWH-073 has been encountered as an ingredient of synthetic cannabis blends in Germany and several other European countries since 2010.[6] The 4'-methoxy derivative JWH-080 is also known to be a potent cannabinoid agonist and has been banned in some countries, though it is unclear if it has also been used in synthetic cannabis smoking blends.

4'-Methyl-JWH-073

Legal status[edit]

United States[edit]

See also: JWH-018
1 g of JWH-073

The US DEA temporarily declared JWH-073 a schedule I controlled substance on 1 March 2011 through 76 FR 11075, and permanently instated the same schedule on 9 July 2012 in the Section 1152 of the Food and Drug Administration Safety and Innovation Act.[7]

Australia[edit]

See also: JWH-018

On 8 July 2011 the AUS government banned the sale of JWH-073.[8]

New Zealand[edit]

On 8 May 2014 the New Zealand government banned the sale of JWH-073. [9]

See also[edit]

References[edit]