JWH-176

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JWH-176
JWH-171.png
Systematic (IUPAC) name
1-([(1E)-3-pentylinden-1-ylidine]methyl)naphthalene
Clinical data
Legal status
  • Legal
Identifiers
CAS number 619294-62-1 YesY
ATC code ?
ChemSpider 29341653
Chemical data
Formula C25H24 
Mol. mass 324.457 g/mol
 YesY (what is this?)  (verify)

JWH-176 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 26.0nM, making it more potent than THC itself,[1] however JWH-176 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor.[2] It was discovered by, and named after, Dr. John W. Huffman.

See also[edit]

References[edit]

  1. ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
  2. ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X