L-759,633

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L-759,633
L-759,633.png
Systematic (IUPAC) name
(6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene
Clinical data
Legal status ?
Identifiers
CAS number  YesY
ATC code ?
PubChem CID 5311215
IUPHAR ligand 748
ChEMBL CHEMBL57367 N
Chemical data
Formula C26H40O2 
Mol. mass 384.593 g/mol
 N (what is this?)  (verify)

L-759,633 is an analgesic drug that is a cannabinoid agonist. It is a fairly selective agonist for the CB2 receptor, with selectivity of 163x for CB2 over CB1.[1]

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.[2][3]

See also[edit]

References[edit]

  1. ^ Ross, RA, Brockie, HC, Stevenson, LA, Murphy, VL, Templeton, F, Makriyannis, A, Pertwee, RG (1999). "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630". British Journal of Pharmacology 126 (3): 665–72. doi:10.1038/sj.bjp.0702351. PMC 1565857. PMID 10188977. 
  2. ^ Huffman, JW (2000). "The search for selective ligands for the CB2 receptor". Current pharmaceutical design 6 (13): 1323–37. doi:10.2174/1381612003399347. PMID 10903395. 
  3. ^ Huffman, JW (2005). "CB2 receptor ligands". Mini reviews in medicinal chemistry 5 (7): 641–9. doi:10.2174/1389557054368844. PMID 16026310.