HU-336

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HU-336
HU-336 molecular structure.png
Systematic (IUPAC) name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-1H-benzo[c]chromene-1,4(6H)-dione
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem CID 11370880
ChemSpider 9545797 YesY
Chemical data
Formula C21H28O3 
Mol. mass 328.445
 YesY (what is this?)  (verify)

HU-336 is a strongly antiangiogenic compound, significantly inhibiting angiogenesis at concentrations as low as 300nM. It inhibits angiogenesis by directly inducing apoptosis of vascular endothelial cells without changing the expression of pro- and antiangiogenic cytokines and their receptors. HU-336 is highly effective against tumor xenografts in nude mice.[1]

See also[edit]

References[edit]

  1. ^ Natalya M. Kogan, et al. (2006). "A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells". Molecular Pharmacology 70 (1): 51–59. doi:10.1124/mol.105.021089. PMID 16571653.