NESS-040C5

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NESS-040C5
NESS-040C5 structure.png
Systematic (IUPAC) name
N-(2-isopropyl-5-methylcyclohexyl)-1-(4-methylbenzyl)-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide
Clinical data
Legal status
  •  ?
Identifiers
CAS number 1445751-90-5
ATC code None
Chemical data
Formula C27H33N3OS 
Mol. mass 447.64 g/mol

NESS-040C5 is a potent cannabinoid agonist which was developed for the treatment of glaucoma.[1] It has reasonable selectivity for the CB2 receptor subtype, having a CB2 affinity of 0.4nM, and 25x selectivity over the related CB1 receptor.[2]

See also[edit]

References[edit]

  1. ^ Paolo Lazzari et al. Pharmaceutical Compounds. US Patent 8106218
  2. ^ Hanus LO, Mechoulam R. Novel natural and synthetic ligands of the endocannabinoid system. Current Medicinal Chemistry. 2010;17(14):1341-59. PMID 20166928