GNB2L1

Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Identifiers
Symbols	GNB2L1; Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1
External IDs	OMIM: 176981 MGI: 101849 HomoloGene: 4446 GeneCards: GNB2L1 Gene
Gene Ontology
Molecular function	• protein kinase C binding; • receptor binding; • protein binding; • ion channel inhibitor activity; • protein phosphatase binding; • protein tyrosine kinase inhibitor activity; • receptor tyrosine kinase binding; • SH2 domain binding;
Cellular component	• phagocytic cup; • nucleus; • cytoplasm; • cytoskeleton; • plasma membrane; • small ribosomal subunit; • dendrite; • midbody; • cell projection; • neuronal cell body; • perikaryon; • perinuclear region of cytoplasm;
Biological process	• positive regulation of protein phosphorylation; • multicellular organismal development; • negative regulation of translation; • negative regulation of Wnt receptor signaling pathway; • negative regulation of cell growth; • positive regulation of cell migration; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • positive regulation of protein homooligomerization; • regulation of protein localization; • regulation of growth; • positive regulation of apoptosis; • positive regulation of GTPase activity; • interspecies interaction between organisms; • rhythmic process; • negative regulation of phagocytosis; • regulation of cell division; • regulation of cell cycle; • negative regulation of protein tyrosine kinase activity; • regulation of establishment of cell polarity; • positive regulation of gastrulation;
	Sources: Amigo / QuickGO
Orthologs

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Guanine nucleotide-binding protein subunit beta-2-like 1 is a protein that in humans is encoded by the GNB2L1 gene.^[1]^[2]

[edit] Interactions

GNB2L1 has been shown to interact with PDE4D,^[3]^[4] STAT1,^[5]^[6] Tyrosine kinase 2,^[5] Src,^[7] Androgen receptor,^[8] AGTRAP,^[9] Janus kinase 1,^[5] FYN,^[10]^[11] Cyclin A1,^[12] IFNAR2,^[6]^[13] PRKCE,^[14] P73,^[15] RAS p21 protein activator 1,^[16] PRKCB1,^[17] ST7,^[18] PTPRM,^[19]^[20] EIF6,^[21] OTUB1,^[22] CD18^[23] and CD29.^[23]^[24]

[edit] See also

G protein

[edit] References

^ Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (Mar 1994). "Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins". Proc Natl Acad Sci U S A 91 (3): 839–43. doi:10.1073/pnas.91.3.839. PMC 521407. PMID 8302854. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=521407.
^ Guillemot F, Billault A, Auffray C (Jul 1989). "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex". Proc Natl Acad Sci U S A 86 (12): 4594–8. doi:10.1073/pnas.86.12.4594. PMC 287317. PMID 2499885. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=287317.
^ Yarwood, S J; Steele M R, Scotland G, Houslay M D, Bolger G B (May. 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. (UNITED STATES) 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. ISSN 0021-9258. PMID 10329691.
^ Steele, M R; McCahill A, Thompson D S, MacKenzie C, Isaacs N W, Houslay M D, Bolger G B (Jul. 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cell. Signal. (England) 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. ISSN 0898-6568. PMID 11516626.
^ ^a ^b ^c Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R (Sep. 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. (United States) 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323.
^ ^a ^b Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (Jun. 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. (United States) 276 (25): 22948–53. doi:10.1074/jbc.M100087200. ISSN 0021-9258. PMID 11301323.
^ Chang, B Y; Conroy K B, Machleder E M, Cartwright C A (Jun. 1998). "RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3245–56. ISSN 0270-7306. PMC 108906. PMID 9584165. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108906.
^ Rigas, Anastasia C; Ozanne Daniel M, Neal David E, Robson Craig N (Nov. 2003). "The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway". J. Biol. Chem. (United States) 278 (46): 46087–93. doi:10.1074/jbc.M306219200. ISSN 0021-9258. PMID 12958311.
^ Wang, Wei; Huang Yan, Zhou Zongxiang, Tang Rong, Zhao Wei, Zeng Li, Xu Ming, Cheng Chao, Gu Shaohua, Ying Kang, Xie Yi, Mao Yumin (Jan. 2002). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int. J. Biochem. Cell Biol. (England) 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. ISSN 1357-2725. PMID 11733189.
^ Yaka, Rami; He Dao-Yao, Phamluong Khanhky, Ron Dorit (Mar. 2003). "Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1". J. Biol. Chem. (United States) 278 (11): 9630–8. doi:10.1074/jbc.M209141200. ISSN 0021-9258. PMID 12524444.
^ Yaka, Rami; Thornton Claire, Vagts Alicia J, Phamluong Khanhky, Bonci Antonello, Ron Dorit (Apr. 2002). "NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5710–5. doi:10.1073/pnas.062046299. ISSN 0027-8424. PMC 122836. PMID 11943848. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122836.
^ Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (Aug. 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. (United States) 279 (32): 33727–41. doi:10.1074/jbc.M401708200. ISSN 0021-9258. PMID 15159402.
^ Croze, E; Usacheva A, Asarnow D, Minshall R D, Perez H D, Colamonici O (Nov. 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. (UNITED STATES) 165 (9): 5127–32. ISSN 0022-1767. PMID 11046044.
^ Liedtke, Carole M; Yun C H Chris, Kyle Nicole, Wang Dandan (Jun. 2002). "Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor". J. Biol. Chem. (United States) 277 (25): 22925–33. doi:10.1074/jbc.M201917200. ISSN 0021-9258. PMID 11956211.
^ Ozaki, Toshinori; Watanabe Ken-ichi, Nakagawa Takahito, Miyazaki Kou, Takahashi Masato, Nakagawara Akira (May. 2003). "Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB". Oncogene (England) 22 (21): 3231–42. doi:10.1038/sj.onc.1206382. ISSN 0950-9232. PMID 12761493.
^ Koehler, J A; Moran M F (May. 2001). "RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP". Biochem. Biophys. Res. Commun. (United States) 283 (4): 888–95. doi:10.1006/bbrc.2001.4889. ISSN 0006-291X. PMID 11350068.
^ Ron, D; Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (Sep. 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. (UNITED STATES) 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. ISSN 0021-9258. PMID 10480917.
^ Battle, Michele A; Maher Veronica M, McCormick J Justin (Jun. 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry (United States) 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483.
^ Hellberg, Carina B; Burden-Gulley Susan M, Pietz Gregory E, Brady-Kalnay Susann M (Mar. 2002). "Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells". J. Biol. Chem. (United States) 277 (13): 11165–73. doi:10.1074/jbc.M112157200. ISSN 0021-9258. PMID 11801604.
^ Mourton, T; Hellberg C B, Burden-Gulley S M, Hinman J, Rhee A, Brady-Kalnay S M (May. 2001). "The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts". J. Biol. Chem. (United States) 276 (18): 14896–901. doi:10.1074/jbc.M010823200. ISSN 0021-9258. PMID 11278757.
^ Ceci, Marcello; Gaviraghi Cristina, Gorrini Chiara, Sala Leonardo A, Offenhäuser Nina, Marchisio Pier Carlo, Biffo Stefano (Dec. 2003). "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly". Nature (England) 426 (6966): 579–84. doi:10.1038/nature02160. PMID 14654845.
^ Edelmann, Mariola J; Iphöfer Alexander, Akutsu Masato, Altun Mikael, di Gleria Katalin, Kramer Holger B, Fiebiger Edda, Dhe-Paganon Sirano, Kessler Benedikt M (Mar. 2009). "Structural basis and specificity of human otubain 1-mediated deubiquitination". Biochem. J. (England) 418 (2): 379–90. doi:10.1042/BJ20081318. PMID 18954305.
^ ^a ^b Liliental, J; Chang D D (Jan. 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085.
^ Lee, H-S; Millward-Sadler S J, Wright M O, Nuki G, Al-Jamal R, Salter D M (Nov. 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthr. Cartil. (England) 10 (11): 890–7. doi:10.1053/joca.2002.0842. ISSN 1063-4584. PMID 12435334.

[edit] Further reading

Liu YV, Semenza GL (2007). "RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.". Cell Cycle 6 (6): 656–9. PMID 17361105.
Mochly-Rosen D, Miller KG, Scheller RH, et al. (1992). "p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.". Biochemistry 31 (35): 8120–4. doi:10.1021/bi00150a003. PMID 1326322.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Pumiglia KM, LeVine H, Haske T, et al. (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase.". J. Biol. Chem. 270 (24): 14251–4. doi:10.1074/jbc.270.24.14251. PMID 7782277.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Disatnik MH, Hernandez-Sotomayor SM, Jones G, et al. (1994). "Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C". Proc. Natl. Acad. Sci. U.S.A. 91 (2): 559–63. doi:10.1073/pnas.91.2.559. PMC 42988. PMID 8290562. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42988.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
Chang BY, Conroy KB, Machleder EM, Cartwright CA (1998). "RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells". Mol. Cell. Biol. 18 (6): 3245–56. PMC 108906. PMID 9584165. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108906.
Rietzler M, Bittner M, Kolanus W, et al. (1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.
Shimohama S, Kamiya S, Taniguchi T, Kimura J (1999). "Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease". Alzheimer disease and associated disorders 12 (4): 384–6. PMID 9876970.
Yarwood SJ, Steele MR, Scotland G, et al. (1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. PMID 10329691.
Ron D, Jiang Z, Yao L, et al. (1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. PMID 10480917.
Geijsen N, Spaargaren M, Raaijmakers JA, et al. (1999). "Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor". Oncogene 18 (36): 5126–30. doi:10.1038/sj.onc.1202896. PMID 10490850.
Smith PR, de Jesus O, Turner D, et al. (2000). "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus". J. Virol. 74 (7): 3082–92. doi:10.1128/JVI.74.7.3082-3092.2000. PMC 111807. PMID 10708423. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=111807.
Ellis JH, Ashman C, Burden MN, et al. (2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". J. Immunol. 164 (11): 5805–14. PMID 10820259.
Croze E, Usacheva A, Asarnow D, et al. (2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. PMID 11046044.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid8302854-0] Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (Mar 1994). "Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins". Proc Natl Acad Sci U S A 91 (3): 839–43. doi:10.1073/pnas.91.3.839. PMC 521407. PMID 8302854. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=521407.

[pmid2499885-1] Guillemot F, Billault A, Auffray C (Jul 1989). "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex". Proc Natl Acad Sci U S A 86 (12): 4594–8. doi:10.1073/pnas.86.12.4594. PMC 287317. PMID 2499885. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=287317.

[pmid10329691-2] Yarwood, S J; Steele M R, Scotland G, Houslay M D, Bolger G B (May. 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. (UNITED STATES) 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. ISSN 0021-9258. PMID 10329691.

[pmid11516626-3] Steele, M R; McCahill A, Thompson D S, MacKenzie C, Isaacs N W, Houslay M D, Bolger G B (Jul. 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cell. Signal. (England) 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. ISSN 0898-6568. PMID 11516626.

[pmid12960323-4] Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R (Sep. 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. (United States) 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323.

[pmid11301323-5] Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (Jun. 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. (United States) 276 (25): 22948–53. doi:10.1074/jbc.M100087200. ISSN 0021-9258. PMID 11301323.

[pmid9584165-6] Chang, B Y; Conroy K B, Machleder E M, Cartwright C A (Jun. 1998). "RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3245–56. ISSN 0270-7306. PMC 108906. PMID 9584165. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108906.

[pmid12958311-7] Rigas, Anastasia C; Ozanne Daniel M, Neal David E, Robson Craig N (Nov. 2003). "The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway". J. Biol. Chem. (United States) 278 (46): 46087–93. doi:10.1074/jbc.M306219200. ISSN 0021-9258. PMID 12958311.

[pmid11733189-8] Wang, Wei; Huang Yan, Zhou Zongxiang, Tang Rong, Zhao Wei, Zeng Li, Xu Ming, Cheng Chao, Gu Shaohua, Ying Kang, Xie Yi, Mao Yumin (Jan. 2002). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int. J. Biochem. Cell Biol. (England) 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. ISSN 1357-2725. PMID 11733189.

[pmid12524444-9] Yaka, Rami; He Dao-Yao, Phamluong Khanhky, Ron Dorit (Mar. 2003). "Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1". J. Biol. Chem. (United States) 278 (11): 9630–8. doi:10.1074/jbc.M209141200. ISSN 0021-9258. PMID 12524444.

[pmid11943848-10] Yaka, Rami; Thornton Claire, Vagts Alicia J, Phamluong Khanhky, Bonci Antonello, Ron Dorit (Apr. 2002). "NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5710–5. doi:10.1073/pnas.062046299. ISSN 0027-8424. PMC 122836. PMID 11943848. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122836.

[pmid15159402-11] Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (Aug. 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. (United States) 279 (32): 33727–41. doi:10.1074/jbc.M401708200. ISSN 0021-9258. PMID 15159402.

[pmid11046044-12] Croze, E; Usacheva A, Asarnow D, Minshall R D, Perez H D, Colamonici O (Nov. 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. (UNITED STATES) 165 (9): 5127–32. ISSN 0022-1767. PMID 11046044.

[pmid11956211-13] Liedtke, Carole M; Yun C H Chris, Kyle Nicole, Wang Dandan (Jun. 2002). "Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor". J. Biol. Chem. (United States) 277 (25): 22925–33. doi:10.1074/jbc.M201917200. ISSN 0021-9258. PMID 11956211.

[pmid12761493-14] Ozaki, Toshinori; Watanabe Ken-ichi, Nakagawa Takahito, Miyazaki Kou, Takahashi Masato, Nakagawara Akira (May. 2003). "Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB". Oncogene (England) 22 (21): 3231–42. doi:10.1038/sj.onc.1206382. ISSN 0950-9232. PMID 12761493.

[pmid11350068-15] Koehler, J A; Moran M F (May. 2001). "RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP". Biochem. Biophys. Res. Commun. (United States) 283 (4): 888–95. doi:10.1006/bbrc.2001.4889. ISSN 0006-291X. PMID 11350068.

[pmid10480917-16] Ron, D; Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (Sep. 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. (UNITED STATES) 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. ISSN 0021-9258. PMID 10480917.

[pmid12809483-17] Battle, Michele A; Maher Veronica M, McCormick J Justin (Jun. 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry (United States) 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483.

[pmid11801604-18] Hellberg, Carina B; Burden-Gulley Susan M, Pietz Gregory E, Brady-Kalnay Susann M (Mar. 2002). "Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells". J. Biol. Chem. (United States) 277 (13): 11165–73. doi:10.1074/jbc.M112157200. ISSN 0021-9258. PMID 11801604.

[pmid11278757-19] Mourton, T; Hellberg C B, Burden-Gulley S M, Hinman J, Rhee A, Brady-Kalnay S M (May. 2001). "The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts". J. Biol. Chem. (United States) 276 (18): 14896–901. doi:10.1074/jbc.M010823200. ISSN 0021-9258. PMID 11278757.

[pmid14654845-20] Ceci, Marcello; Gaviraghi Cristina, Gorrini Chiara, Sala Leonardo A, Offenhäuser Nina, Marchisio Pier Carlo, Biffo Stefano (Dec. 2003). "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly". Nature (England) 426 (6966): 579–84. doi:10.1038/nature02160. PMID 14654845.

[pmid18954305-21] Edelmann, Mariola J; Iphöfer Alexander, Akutsu Masato, Altun Mikael, di Gleria Katalin, Kramer Holger B, Fiebiger Edda, Dhe-Paganon Sirano, Kessler Benedikt M (Mar. 2009). "Structural basis and specificity of human otubain 1-mediated deubiquitination". Biochem. J. (England) 418 (2): 379–90. doi:10.1042/BJ20081318. PMID 18954305.

[pmid9442085-22] Liliental, J; Chang D D (Jan. 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085.

[pmid12435334-23] Lee, H-S; Millward-Sadler S J, Wright M O, Nuki G, Al-Jamal R, Salter D M (Nov. 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthr. Cartil. (England) 10 (11): 890–7. doi:10.1053/joca.2002.0842. ISSN 1063-4584. PMID 12435334.

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GNB2L1

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[edit] See also

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