IFNAR2

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Interferon (alpha, beta and omega) receptor 2
Protein IFNAR2 PDB 1n6u.png
PDB rendering based on 1n6u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IFNAR2 ; IFN-R; IFN-alpha-REC; IFNABR; IFNARB
External IDs OMIM602376 MGI1098243 HomoloGene49242 ChEMBL: 2005 GeneCards: IFNAR2 Gene
RNA expression pattern
PBB GE IFNAR2 204786 s at tn.png
PBB GE IFNAR2 204785 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3455 15976
Ensembl ENSG00000159110 ENSMUSG00000022971
UniProt P48551 O35664
RefSeq (mRNA) NM_000874 NM_001110498
RefSeq (protein) NP_000865 NP_001103968
Location (UCSC) Chr 21:
34.6 – 34.64 Mb
Chr 16:
91.37 – 91.41 Mb
PubMed search [1] [2]

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[1]

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[2]

Interactions[edit]

IFNAR2 has been shown to interact with STAT2,[3][4] STAT1,[3][5] GNB2L1[5][6] and IFNA2.[7]

References[edit]

  1. ^ Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059. 
  2. ^ "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2". 
  3. ^ a b Li, X; Leung S; Kerr I M; Stark G R (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. (UNITED STATES) 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453. 
  4. ^ Nguyen, Vinh-Phúc; Saleh Abu Z M; Arch Allison E; Yan Hai; Piazza Flavia; Kim John; Krolewski John J (March 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. (United States) 277 (12): 9713–21. doi:10.1074/jbc.M111161200. ISSN 0021-9258. PMID 11786546. 
  5. ^ a b Usacheva, A; Smith R; Minshall R; Baida G; Seng S; Croze E; Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. (United States) 276 (25): 22948–53. doi:10.1074/jbc.M100087200. ISSN 0021-9258. PMID 11301323. 
  6. ^ Croze, E; Usacheva A; Asarnow D; Minshall R D; Perez H D; Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. (UNITED STATES) 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. ISSN 0022-1767. PMID 11046044. 
  7. ^ Piehler, J; Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. (ENGLAND) 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. ISSN 0022-2836. PMID 10339405. 

Further reading[edit]

  • Caraglia M, Marra M, Pelaia G, et al. (2005). "Alpha-interferon and its effects on signal transduction pathways.". J. Cell. Physiol. 202 (2): 323–35. doi:10.1002/jcp.20137. PMID 15389589. 
  • Raz R, Cheung K, Ling L, Levy DE (1995). "Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness.". Somat. Cell Mol. Genet. 21 (2): 139–45. doi:10.1007/BF02255789. PMID 7570186. 
  • Lutfalla G, Holland SJ, Cinato E, et al. (1995). "Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.". EMBO J. 14 (20): 5100–8. PMC 394613. PMID 7588638. 
  • Domanski P, Witte M, Kellum M, et al. (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.". J. Biol. Chem. 270 (37): 21606–11. doi:10.1074/jbc.270.37.21606. PMID 7665574. 
  • Novick D, Cohen B, Tal N, Rubinstein M (1995). "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor.". J. Leukoc. Biol. 57 (5): 712–8. PMID 7759950. 
  • Platanias LC, Uddin S, Domanski P, Colamonici OR (1996). "Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor.". J. Biol. Chem. 271 (39): 23630–3. doi:10.1074/jbc.271.39.23630. PMID 8798579. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Croze E, Russell-Harde D, Wagner TC, et al. (1997). "The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein.". J. Biol. Chem. 271 (52): 33165–8. doi:10.1074/jbc.271.52.33165. PMID 8969169. 
  • Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.". Mol. Cell. Biol. 17 (4): 2048–56. PMC 232052. PMID 9121453. 
  • Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2.". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405. 
  • Chuntharapai A, Gibbs V, Lu J, et al. (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2.". J. Immunol. 163 (2): 766–73. PMID 10395669. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
  • Croze E, Usacheva A, Asarnow D, et al. (2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor.". J. Immunol. 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. PMID 11046044. 
  • Usacheva A, Smith R, Minshall R, et al. (2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor.". J. Biol. Chem. 276 (25): 22948–53. doi:10.1074/jbc.M100087200. PMID 11301323. 
  • Nguyen VP, Saleh AZ, Arch AE, et al. (2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling.". J. Biol. Chem. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546. 
  • Chill JH, Nivasch R, Levy R, et al. (2002). "The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening.". Biochemistry 41 (11): 3575–85. doi:10.1021/bi011778f. PMID 11888273. 
  • Velichko S, Wagner TC, Turkson J, et al. (2002). "STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.". J. Biol. Chem. 277 (38): 35635–41. doi:10.1074/jbc.M204578200. PMID 12105218. 
  • Usacheva A, Kotenko S, Witte MM, Colamonici OR (2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.". J. Immunol. 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. PMID 12133952. 
  • Gauzzi MC, Canini I, Eid P, et al. (2002). "Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells.". J. Immunol. 169 (6): 3038–45. doi:10.4049/jimmunol.169.6.3038. PMID 12218119.