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OPK-88004

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OPK-88004
Legal status
Legal status
  • US: Investigational drug
Identifiers
  • propan-2-yl N-[(2S)-7-cyano-4-(pyridin-2-ylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H22N4O2
Molar mass374.4 g·mol−1
3D model (JSmol)
  • CC(C)OC(=O)N[C@H]1CC2=C(C1)N(C3=C2C=C(C=C3)C#N)CC4=CC=CC=N4
  • InChI=1S/C22H22N4O2/c1-14(2)28-22(27)25-17-10-19-18-9-15(12-23)6-7-20(18)26(21(19)11-17)13-16-5-3-4-8-24-16/h3-9,14,17H,10-11,13H2,1-2H3,(H,25,27)/t17-/m0/s1
  • Key:IHIWYQYVBNODSV-KRWDZBQOSA-N

LY-2452473 (TT-701) is a drug which acts as a selective androgen receptor modulator (SARM). It has been investigated for the treatment of erectile dysfunction and symptoms associated with benign prostate hyperplasia.[1][2]

See also

References

  1. ^ Yi P, Rehmel JF, Cassidy K, Hadden C, Campanale K, Patel N, Johnson J (December 2012). "Disposition and metabolism of LY2452473, a selective androgen receptor modulator, in humans". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 40 (12): 2354–64. doi:10.1124/dmd.112.047613. PMID 22961682. S2CID 6942291.
  2. ^ Noey EL, Yang Z, Li Y, Yu H, Richey RN, Merritt JM, Kjell DP, Houk KN (June 2017). "Origins of Regioselectivity in the Fischer Indole Synthesis of a Selective Androgen Receptor Modulator". The Journal of Organic Chemistry. 82 (11): 5904–5909. doi:10.1021/acs.joc.7b00878. PMID 28467062.
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