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Insulin-like growth factor binding protein 1
Protein IGFBP1 PDB 1zt3.png
PDB rendering based on 1zt3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IGFBP1 ; AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1
External IDs OMIM146730 MGI96436 HomoloGene498 ChEMBL: 4178 GeneCards: IGFBP1 Gene
RNA expression pattern
PBB GE IGFBP1 205302 at tn.png
More reference expression data
Species Human Mouse
Entrez 3484 16006
Ensembl ENSG00000146678 ENSMUSG00000020429
UniProt P08833 P47876
RefSeq (mRNA) NM_000596 NM_008341
RefSeq (protein) NP_000587 NP_032367
Location (UCSC) Chr 7:
45.89 – 45.89 Mb
Chr 11:
7.2 – 7.2 Mb
PubMed search [1] [2]

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.[1][2]


This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


Further reading[edit]

  • Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744. 
  • Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions.". Horm. Res. 51 (2): 53–67. doi:10.1159/000023315. PMID 10352394. 
  • Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191. 
  • Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461. 
  • Ehrenborg E, Larsson C, Stern I, et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.". Genomics 12 (3): 497–502. doi:10.1016/0888-7543(92)90440-4. PMID 1373120. 
  • Ekstrand J, Ehrenborg E, Stern I, et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12.". Genomics 6 (3): 413–8. doi:10.1016/0888-7543(90)90470-F. PMID 1691735. 
  • Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1.". J. Biol. Chem. 265 (34): 21185–93. PMID 1701175. 
  • Brinkman A, Kortleve DJ, Schuller AG, et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.". FEBS Lett. 291 (2): 264–8. doi:10.1016/0014-5793(91)81298-M. PMID 1718783. 
  • Brewer MT, Stetler GL, Squires CH, et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein.". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. doi:10.1016/S0006-291X(88)80425-X. PMID 2454104. 
  • Julkunen M, Koistinen R, Aalto-Setälä K, et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.". FEBS Lett. 236 (2): 295–302. doi:10.1016/0014-5793(88)80041-3. PMID 2457513. 
  • Lee YL, Hintz RL, James PM, et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.". Mol. Endocrinol. 2 (5): 404–11. doi:10.1210/mend-2-5-404. PMID 2458522. 
  • Luthman H, Söderling-Barros J, Persson B, et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.". Eur. J. Biochem. 180 (2): 259–65. doi:10.1111/j.1432-1033.1989.tb14641.x. PMID 2466665. 
  • Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.". Mol. Endocrinol. 3 (5): 846–51. doi:10.1210/mend-3-5-846. PMID 2474129. 
  • Alitalo T, Kontula K, Koistinen R, et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism.". Hum. Genet. 83 (4): 335–8. doi:10.1007/BF00291377. PMID 2478445. 
  • Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.". Biochem. Biophys. Res. Commun. 157 (3): 898–907. doi:10.1016/S0006-291X(88)80959-8. PMID 2849945. 
  • Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.". J. Biol. Chem. 263 (28): 14203–10. PMID 2971653. 
  • Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.". Nucleic Acids Res. 16 (17): 8711. doi:10.1093/nar/16.17.8711. PMC 338590. PMID 3419931. 
  • Jones JI, Gockerman A, Busby WH, et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553–7. doi:10.1073/pnas.90.22.10553. PMC 47815. PMID 7504269. 
  • Jones JI, Busby WH, Wright G, et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.". J. Biol. Chem. 268 (2): 1125–31. PMID 7678248.