Interleukin-18 receptor

interleukin 18 receptor accessory protein
interleukin 18 receptor accessory protein
Identifiers
Symbol	IL18RAP
Alt. symbols	AcPL, CD218b
NCBI gene	8807
HGNC	5989
OMIM	604509
RefSeq	NM_003853
UniProt	O95256
Other data
Locus	Chr. 2 p24.3-24.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

interleukin 18 receptor 1
interleukin 18 receptor 1
Identifiers
Symbol	IL18R1
Alt. symbols	IL1RRP, IL-1Rrp, CD218a
NCBI gene	8809
HGNC	5988
OMIM	604494
RefSeq	NM_003855
UniProt	Q13478
Other data
Locus	Chr. 2 q12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.^[1]^[2] IL-18R is a heteromeric complex of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.

Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.^[3]

References

^ Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361.
^ Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility. 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.

External links

Receptors,+Interleukin-18 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid15323361-1] Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361.

[pmid12759435-2] Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[3] Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility. 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.

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