IL18R1

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IL18R1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP, interleukin 18 receptor 1
External IDs MGI: 105383 HomoloGene: 2861 GeneCards: 8809
Genetically Related Diseases
Disease Name References
asthma
RNA expression pattern
PBB GE IL18R1 206618 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282399
NM_003855

NM_001161842
NM_001161843
NM_008365

RefSeq (protein)

NP_001269328.1
NP_003846.1

NP_032391.1

Location (UCSC) Chr 2: 102.31 – 102.4 Mb Chr 1: 40.47 – 40.5 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[4] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[4]

See also[edit]

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Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.