From Wikipedia, the free encyclopedia
Jump to: navigation, search
Interleukin 18 receptor 1
Symbols IL18R1 ; CD218a; CDw218a; IL-1Rrp; IL18RA; IL1RRP
External IDs OMIM604494 MGI105383 HomoloGene2861 IUPHAR: 1737 GeneCards: IL18R1 Gene
RNA expression pattern
PBB GE IL18R1 206618 at tn.png
More reference expression data
Species Human Mouse
Entrez 8809 16182
Ensembl ENSG00000115604 ENSMUSG00000026070
UniProt Q13478 Q61098
RefSeq (mRNA) NM_001282399 NM_001161842
RefSeq (protein) NP_001269328 NP_001155314
Location (UCSC) Chr 2:
102.93 – 103.02 Mb
Chr 1:
40.47 – 40.5 Mb
PubMed search [1] [2]

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[1] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[1]

See also[edit]


Further reading[edit]

  • Sergi B, Penttila I (2005). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361. 
  • Parnet P; Garka KE; Bonnert TP et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725. 
  • Lovenberg TW; Crowe PD; Liu C et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. 
  • Torigoe K; Ushio S; Okura T et al. (1997). "Purification and characterization of the human interleukin-18 receptor". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300. 
  • Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101. 
  • Hoshino K; Tsutsui H; Kawai T et al. (1999). "Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor". J. Immunol. 162 (9): 5041–4. PMID 10227969. 
  • Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells". J. Immunol. 165 (4): 1933–8. doi:10.4049/jimmunol.165.4.1933. PMID 10925275. 
  • Kumar S; Hanning CR; Brigham-Burke MR et al. (2003). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production". Cytokine 18 (2): 61–71. doi:10.1006/cyto.2002.0873. PMID 12096920. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Gutzmer R; Langer K; Mommert S et al. (2004). "Human dendritic cells express the IL-18R and are chemoattracted to IL-18". J. Immunol. 171 (12): 6363–71. doi:10.4049/jimmunol.171.12.6363. PMID 14662834. 
  • Azam T; Novick D; Bufler P et al. (2004). "Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex". J. Immunol. 171 (12): 6574–80. doi:10.4049/jimmunol.171.12.6574. PMID 14662859. 
  • Towne JE; Garka KE; Renshaw BR et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551. 
  • Cardoso SP, Keen L, Bidwell J (2004). "Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha". Eur. J. Immunogenet. 31 (1): 27–9. doi:10.1111/j.1365-2370.2004.00441.x. PMID 15009178. 
  • Reddy SA; Lin YF; Huang HJ et al. (2004). "The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation". Biochem. Biophys. Res. Commun. 316 (4): 1022–8. doi:10.1016/j.bbrc.2004.02.155. PMID 15044087. 
  • Yoon- DY; Cho YS; Park JW et al. (2005). "Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor". Clin. Chem. Lab. Med. 42 (5): 499–506. doi:10.1515/CCLM.2004.085. PMID 15202785. 
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production". J. Biol. Chem. 280 (18): 18056–62. doi:10.1074/jbc.M413297200. PMID 15760905. 
  • Hillier LW; Graves TA; Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  • Sahar S; Dwarakanath RS; Reddy MA et al. (2005). "Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis". Circ. Res. 96 (10): 1064–71. doi:10.1161/01.RES.0000168210.10358.f4. PMID 15860756. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.