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Interleukin 18 receptor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL18R1 ; CD218a; CDw218a; IL-1Rrp; IL18RA; IL1RRP
External IDs OMIM604494 MGI105383 HomoloGene2861 GeneCards: IL18R1 Gene
RNA expression pattern
PBB GE IL18R1 206618 at tn.png
More reference expression data
Species Human Mouse
Entrez 8809 16182
Ensembl ENSG00000115604 ENSMUSG00000026070
UniProt Q13478 Q61098
RefSeq (mRNA) NM_001282399 NM_001161842
RefSeq (protein) NP_001269328 NP_001155314
Location (UCSC) Chr 2:
102.31 – 102.4 Mb
Chr 1:
40.47 – 40.5 Mb
PubMed search [1] [2]

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[1] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.