ACKR3

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ACKR3
Identifiers
AliasesACKR3, CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1, atypical chemokine receptor 3
External IDsMGI: 109562 HomoloGene: 22419 GeneCards: ACKR3
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ACKR3
Genomic location for ACKR3
Band2q37.3Start236,567,787 bp[1]
End236,582,358 bp[1]
RNA expression pattern
PBB GE CXCR7 212977 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001047841
NM_020311

NM_001271607
NM_007722

RefSeq (protein)

NP_064707

NP_001258536
NP_031748

Location (UCSC)Chr 2: 236.57 – 236.58 MbChr 1: 90.2 – 90.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene.[5][6]

This gene encodes a member of the G protein-coupled receptor family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.[6]

However, another recent study has provided evidence that ligand binding to CXCR7 activates MAP kinases through Beta-arrestins, and thus has functions beyond ligand sequestration.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144476 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044337 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F (October 2005). "The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes". The Journal of Biological Chemistry. 280 (42): 35760–6. doi:10.1074/jbc.M508234200. PMID 16107333. 
  6. ^ a b "Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7". 
  7. ^ * Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, Gerard NP, Gerard C, Lefkowitz RJ (January 2010). "Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7". Proceedings of the National Academy of Sciences of the United States of America. 107 (2): 628–32. doi:10.1073/pnas.0912852107. PMC 2818968Freely accessible. PMID 20018651. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.