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Interleukin 13 receptor, alpha 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL13RA2 ; CD213A2; CT19; IL-13R; IL13BP
External IDs OMIM300130 MGI1277954 HomoloGene534 GeneCards: IL13RA2 Gene
RNA expression pattern
PBB GE IL13RA2 206172 at tn.png
More reference expression data
Species Human Mouse
Entrez 3598 16165
Ensembl ENSG00000123496 ENSMUSG00000031289
UniProt Q14627 O88786
RefSeq (mRNA) NM_000640 NM_001306059
RefSeq (protein) NP_000631 NP_001292988
Location (UCSC) Chr X:
115 – 115.02 Mb
Chr X:
147.38 – 147.43 Mb
PubMed search [1] [2]

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[1]


IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.