IL13RA2

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IL13RA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDsMGI: 1277954 HomoloGene: 534 GeneCards: IL13RA2
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for IL13RA2
Genomic location for IL13RA2
BandXq23Start115,003,975 bp[1]
End115,019,977 bp[1]
RNA expression pattern
PBB GE IL13RA2 206172 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000640

NM_008356
NM_001306059

RefSeq (protein)

NP_000631

NP_001292988
NP_032382

Location (UCSC)Chr X: 115 – 115.02 MbChr X: 147.38 – 147.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[5]

Function[edit]

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[5]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.