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Tumor necrosis factor receptor superfamily, member 12A
Protein TNFRSF12A PDB 2EQP.png
Rendering based on PDB 2EQP​.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TNFRSF12A ; CD266; FN14; TWEAKR
External IDs OMIM605914 MGI1351484 HomoloGene8451 IUPHAR: 1884 GeneCards: TNFRSF12A Gene
RNA expression pattern
PBB GE TNFRSF12A 218368 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51330 27279
Ensembl ENSG00000006327 ENSMUSG00000023905
UniProt Q9NP84 Q9CR75
RefSeq (mRNA) NM_016639 NM_001161746
RefSeq (protein) NP_057723 NP_001155218
Location (UCSC) Chr 16:
3.02 – 3.02 Mb
Chr 17:
23.68 – 23.68 Mb
PubMed search [1] [2]

Tumor necrosis factor receptor superfamily member 12A also known as the Tweak-receptor (TweakR) is a protein that in humans is encoded by the TNFRSF12A gene.[1][2][3]

Clinical significance[edit]

NFAT1 regulates the expression of TWEAKR (this protein) and its ligand TWEAK with lipocalin 2 to increase breast cancer cell invasion.[4]


  1. ^ Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA (Jun 2000). "The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas". Am J Pathol 156 (4): 1253–61. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351. 
  2. ^ Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA (Jan 2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J Biol Chem 274 (46): 33166–76. doi:10.1074/jbc.274.46.33166. PMID 10551889. 
  3. ^ "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A". 
  4. ^ Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S (October 2012). "Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion". J. Cell. Sci. 125 (Pt 19): 4475–86. doi:10.1242/jcs.099879. PMID 22767506. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.