CXCR6

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CXCR6
Identifiers
AliasesCXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDsMGI: 1934582 HomoloGene: 38197 GeneCards: CXCR6
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CXCR6
Genomic location for CXCR6
Band3p21.31Start45,940,933 bp[1]
End45,948,353 bp[1]
RNA expression pattern
PBB GE CXCR6 206974 at fs.png

PBB GE CXCR6 211469 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006564

NM_030712

RefSeq (protein)

NP_006555

NP_109637

Location (UCSC)Chr 3: 45.94 – 45.95 MbChr 9: 123.81 – 123.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[5][6][7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[5][6][7][8] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172215 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048521 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (June 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". The Journal of Experimental Medicine. 185 (11): 2015–23. doi:10.1084/jem.185.11.2015. PMC 2196334Freely accessible. PMID 9166430. 
  6. ^ a b Deng HK, Unutmaz D, KewalRamani VN, Littman DR (July 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature. 388 (6639): 296–300. doi:10.1038/40894. PMID 9230441. 
  7. ^ a b "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6". 
  8. ^ a b Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG (September 2015). "Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV". Journal of Virology. 89 (18): 9252–61. doi:10.1128/JVI.01236-15. PMC 4542357Freely accessible. PMID 26109719. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.