CD27

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CD27 molecule
Identifiers
Symbols CD27 ; S152; S152. LPFS2; T14; TNFRSF7; Tp55
External IDs OMIM186711 MGI88326 HomoloGene74386 GeneCards: CD27 Gene
RNA expression pattern
PBB GE CD27 206150 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 939 21940
Ensembl ENSG00000139193 ENSMUSG00000030336
UniProt P26842 P41272
RefSeq (mRNA) NM_001242 NM_001033126
RefSeq (protein) NP_001233 NP_001028298
Location (UCSC) Chr 12:
6.44 – 6.45 Mb
Chr 6:
125.23 – 125.24 Mb
PubMed search [1] [2]

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.

Function[edit]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.[1]

Interactions[edit]

CD27 has been shown to interact with SIVA1,[2] TRAF2[3][4] and TRAF3.[3][4]

References[edit]

  1. ^ "Entrez Gene: CD27 CD27 molecule". 
  2. ^ Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jun 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proceedings of the National Academy of Sciences of the United States of America 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. PMC 21052. PMID 9177220. 
  3. ^ a b Yamamoto H, Kishimoto T, Minamoto S (Nov 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". Journal of Immunology 161 (9): 4753–9. PMID 9794406. 
  4. ^ a b Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". The Journal of Biological Chemistry 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. PMID 9582383. 

Further reading[edit]

  • Lens SM, de Jong R, Hintzen RQ, Koopman G, van Lier RA, van Oers RH (Jun 1995). "CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth". Leukemia & Lymphoma 18 (1-2): 51–9. doi:10.3109/10428199509064922. PMID 8580829. 
  • Agematsu K (Apr 2000). "Memory B cells and CD27". Histology and Histopathology 15 (2): 573–6. PMID 10809378. 
  • van Baarle D, Kostense S, van Oers MH, Hamann D, Miedema F (Dec 2002). "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue". Trends in Immunology 23 (12): 586–91. doi:10.1016/S1471-4906(02)02326-8. PMID 12464570. 
  • Dörner T, Lipsky PE (2005). "Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus". Lupus 13 (5): 283–9. doi:10.1191/0961203304lu1014oa. PMID 15230280. 

External links[edit]