HU-308

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HU-308
HU-308.png
Systematic (IUPAC) name
[(1R,2R,5R)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-7,7-dimethyl-4-bicyclo[3.1.1]hept-3-enyl] methanol
Clinical data
Legal status Legal
Identifiers
CAS number 256934-39-1 YesY
ATC code ?
PubChem CID 5311172
UNII 8I5L034D55 YesY
Chemical data
Formula C27H43O3 
Mol. mass 415.63 g/mol
 YesY (what is this?)  (verify)

HU-308 is a drug that acts as a cannabinoid agonist. It is highly selective for the CB2 receptor subtype, with a selectivity of over 5000x for CB2 vs CB1.[1] The synthesis and characterization took place in the laboratory of Prof. Mechoulam at the Hebrew University of Jerusalem in the late 1990s. It has analgesic effects,[2] promotes proliferation of neural stem cells,[3] and protects both liver and blood vessel tissues against oxidative stress via inhibition of TNF-α.[4][5]

See also[edit]

References[edit]

  1. ^ Hanus, L., et al. (1999). "HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor". Proceedings of the National Academy of Sciences of the United States of America 96 (25): 14228–14233. Bibcode:1999PNAS...9614228H. doi:10.1073/pnas.96.25.14228. PMC 24419. PMID 10588688.   edit
  2. ^ Labuda, C.; Koblish, M.; Little, P. (2005). "Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain". European Journal of Pharmacology 527 (1–3): 172–174. doi:10.1016/j.ejphar.2005.10.020. PMID 16316653.  edit
  3. ^ Palazuelos, J., et al. (2006). "Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20 (13): 2405–2407. doi:10.1096/fj.06-6164fje. PMID 17015409.   edit
  4. ^ Rajesh, M.; Pan, H.; Mukhopadhyay, P.; Batkai, S.; Osei-Hyiaman, D.; Hasko, G.; Liaudet, L.; Gao, B.; Pacher, P. (2007). "Pivotal Advance: Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis". Journal of leukocyte biology 82 (6): 1382–1389. doi:10.1189/jlb.0307180. PMC 2225476. PMID 17652447.   edit
  5. ^ Rajesh, M., et al. (2007). "CB2-receptor stimulation attenuates TNF-α-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion". American journal of physiology. Heart and circulatory physiology 293 (4): H2210–H2218. doi:10.1152/ajpheart.00688.2007. PMC 2229632. PMID 17660390.   edit