250 - Denis (or Denys or Dionysius) is sent from Rome along with six other missionaries to establish the church in Paris
270 - Death of Gregory Thaumaturgus, Christian leader in Pontus. It was said that when Gregory became "bishop" there were only 17 Christians in Pontus while at his death thirty years later there were only 17 non-Christians.
280 - First rural churches emerge in northern Italy; Christianity is no longer exclusively in urban areas
287 - Maurice from Egypt is killed at Agauno, Switzerland for refusing to sacrifice to pagan divinities
300 - First Christians reported in Greater Khorasan; an estimated 10% of the world's population is now Christian; parts of the Bible are available in 10 different languages
330 - Ethiopian King Ezana of Axum makes Christianity an official religion
332 - Two young Roman Christians, Frumentius and Aedesius, are the sole survivors of a ship destroyed in the Red Sea due to tensions between Rome and Aksum. They are taken as slaves to the Ethiopian capital of Axum to serve in the royal court.
334 - The first bishop is ordained for Merv / Transoxiana (area of modern-day Uzbekistan, Tajikistan, Turkmenistan and southwest Kazakhstan) 
397 - Ninian evangelizes the Southern Picts of Scotland; three missionaries sent to the mountaineers in the Trento region of northern Italy are martyred 
400 - Hayyan begins proclaiming gospel in Yemen after having been converted in Hirta on the Persian border; in starting a school for native Gothic evangelists, John Chrysostom writes, "'Go and make disciples of all nations' was not said for the Apostles onlyu, but for us also"
578 - Conversion to Christianity of An-numan III, last of Lakhmids (Pre Islam Arab prince)
592 - Death of Celtic/Irish missionary Moluag (Old Irish: Mo-Luóc)
596 - Gregory the Great sends Augustine and a team of missionaries to (what is now) England to reintroduce the Gospel. The missionaries settle in Canterbury and within a year baptize 10,000 people 
600 - First Christian settlers in Andorra (between France and Spain)
826 - Ansgar from France is sent by papal authority to Denmark as a royal chaplain and missionary; Harald Klak is baptized along with 400 of his followers at Mainz 
828 - First Christian church in present-day Slovakia is built in Nitra; First missionaries reach the area that is now the Czech Republic
830 - Scotch-born Erluph is evangelizing in (what is now) Germany when he is killed by the Vandals
859 - Execution of Eulogius, proponent of confrontational Christian witness in Spain and other Muslim-dominated societies. Opposed to any feeling of affinity with Muslim culture, Eulogius advocated using a missiology of martyrdom to confront Islam.
1015 - Russia is said to have been "comprehensively" converted to the Orthodox faith; Olaf II Haroldsson becomes the first king of the whole of Norway. Over the next 15 years he would organize Norway's final conversion and its integration into Christian Europe.
1017 - Günther tries to convert the inhabitants of Vorpommern; the mission is not successful.
1266 - Mongol leader Khan sends Marco Polo's father and uncle, Niccolo and Matteo Polo, back to Europe with a request to the Pope to send 100 Christian missionaries (only two responded and one died before reaching Mongol territory) 
1389 - Large numbers of Christians march through the streets of Cairo, denouncing Islam and lamenting that they had abandoned the religion of their fathers from fear of pesecution. They were beheaded, both men and women, and a fresh persecution of Christians followed 
1491 - The Congo sees its first group of missionaries arrive. Under the ministry of these Franciscan and Dominican priests, the king would soon be baptized and a church built at the royal capital.
1511 - Martin de Valencia came to believe that Psalm 58 prophesied the conversion of all unbelievers. While reflecting on the Scripture passage, he asked, "When will this be? When will this prophecy be filled . . . we are already in the afternoon, at the end of our days, and the world's final era." Later that same week, while reading aloud from the prophet Isaiah, he reportedly saw a vision of vast multitudes being converted and baptised. He began to pray to be chosen to preach and convert all heathen. He would die 20 years later as a missionary to Mexico.
1544 - Franciscan Andrés de Olmos, leads group of Indian converts to Tamaulipas
1545 - Testifying to the power that letters back home from missionaries have had, Antonio Araoz writes about Francis Xavier: "No less fruit has been obtained in Spain and Portugal through his letters than has been obtained in the Indies through his teaching."
1549 Jesuit missionaries led by Xavier arrive in Japan and built a base in Kyushu. Their aggressive proselytizing was most successful in Kyushu, with about 100,000 to 200,000 converts, including many daimyo.
1550 - Printed Scriptures are available in 28 languages
1563 - Jesuit missionary Luis Frois, who will later write a history of Jesuit activity in Japan, arrives in that country; Omura Sumitada becomes the first daimyo (feudal landholder) to convert to Christianity
1574 - Augustinian Guillermo de Santa Maria writes a treatise on the illegitimacy of the war the Spanish government was waging against the Chichimeca in the Mexican state of Michoacán
1575 - Church building constructed in Kyoto. Built in Japanese architectural style, it was popularly called the "temple of the South Barbarians"
1575 - Spanish Augustinians Martín de Rada and Geronimo Martín spend four months in Fujian, China, trying to arrange for long-term missionary work there. The attempt ends in failure due to unrelated events in the Philippines.
1579 - Jesuit Alessandro Valignano arrives in Japan where, as "Visitor of Missions", he formulates a basic strategy for Catholic proselytism in that country. Valignano's adaptationism attempted to avoid cultural frictions by covering the gap between certain Japanese customs and Roman Catholic values.
1580 - Japanese Daimyo (feudal landholder) Arima Harunobu becomes Christian and takes the name Protasio
1583 - Five Jesuit missionaries are murdered near Goa (India)
1584 - Matteo Ricci and a Chinese scholar translate a catechism into Chinese under the title Tian Zhu Shi Lu（天主實録） (A True Account of God)
1585 - Carmelite leader Jerome Gracian meets with Martin Ignatius de Loyola, a Franciscan missionary from China. The two sign a vinculo de hermandad misionera—a bond of missionary brotherhood—by which the two orders would collaborate in missionary work in Ethiopia, China, the Philippines, and the East and West Indies.
1586 - Portuguese missionary João dos Santos reports that locals kill elephants to protect their crops in Sofala, Mozambique.
1587 - All foreigners ordered out of Japan when shogun fears they are as divisive and might present the Europeans with an opportunity to disrupt Japan. They stay but persecution escalates.
Manteo becomes the first American Indian to be baptized by the Church of England
1590 - A book by Belgian pastor Hadrian à Saravia has a chapter arguing that the Great Commission is still binding on the church today because the Apostles did not fulfill it completely 
1591 - First Catholic church built in Trinidad; First Chinese admitted as members of the Jesuit order
1593 - The Franciscans arrive in Japan and establish St. Anna's hospital in Kyoto; they dispute with the Jesuits.
1594 - First Jesuit missionaries arrive in what is today Pakistan
1596 - Jesuit missionaries travel across the island of Samar in the Philippines to establish mission centers on the eastern side
1597 - Twenty-six Japanese Christians are crucified for their faith by General Toyotomi Hideyoshi in Nagasaki, Japan. Full-scale persecution destroys the Christian community by the 1620s. Converts who did not reject Christianity were killed. Many Christians went underground, but their communities died out. Christianity left no permanent imprint on Japanese society.
1598 - Spanish missionaries push north from Mexico into what is now the state of New Mexico .
1623 - A stone monument (Nestorian Stele) is unearthed in Xi'an (Si-ngan-fu), China. Its inscription, written by a Syrian monk almost a thousand years earlier and in both Chinese characters and Persian script, begins with the words, "Let us praise the Lord that the [Christian] faith has been popular in China"; it told of the arrival of a missionary, A-lo-pen (Abraham), in AD 625. Alvaro Semedo and other Jesuits soon publicize the stele's discovery in Europe.
1624 - Persecution intensifies in Japan with 50 Christians being burned alive in Edo (now called Tokyo)
1630 - An attempt is made in the El Paso, Texas area to establish a mission among the Mansos Indians
1631 - Dutch missionary Abraham Rogerius (anglicized as Roger), who authored Open Door to the Secrets of Heathendom, begins 10 years of ministry among the Tamil people in the Dutch colony of Pulicat near Madras, India 
1632 - Zuni Indians murder a group of Franciscan missionaries who had three years earlier established the first mission to the Zunis at Hawikuh in what is now New Mexico
1634 - Jesuit missionary Jean de Brèbeuf travels to the Petun nation (in Canada) and baptizes a 40-year-old man.
1635 - An expedition of Franciscans leaves Quito, Ecuador, to try to penetrate into Amazonia from the west. Though most of them will be killed along the way, a few will manage to arrive two years later on the Atlantic coast.
1636 - The Dominicans of Manila (the Philippines) organize a missionary expedition to Japan. They are arrested on one of the Okinawa islands and will be eventually condemned to death by the tribunal of Nagasaki.
1638 - Official ban of Christianity in Japan with death penalty; The Fountain Opened, a posthumous work of the influential Puritan writer Richard Sibbes is published, in which he says that the gospel must continue its journey "til it have gone over the whole world."
1641 - Jesuit missionary Cristoval de Acuna describes the Amazon River in a written report to the king of Spain
1642 - Catholic missionaries Isaac Jogues and Rene Goupil are captured by Mohawk Indians as they return to Huron country from Quebec. Goupil was tomahawked to death while Jogues will be held for a period of time as a slave. He used his slavery as an opportunity for missionary work 
1657 - Thomas Mayhew, Jr., is lost at sea during a voyage to England that was to combine an appeal for missionary funds with personal business
1658 - After the flight of the French missionaries from his area, chief Daniel Garakonthie of the Onondaga Indians, examines the customs of the French colonists and the doctrines of the missionaries and openly begins protecting Christians in his part of what is now New York
1664 - Justinian Von Welz authors three powerful pamphlets on the need for world missions; he will go to Dutch Guinea (now called Surinam) where he will die after only three months
1665 - Japanese feudal landholders (called Daimyo) were ordered to follow the shogunate's example and to appoint inquisitors to do a yearly scutiny of Christians
1666 -John Eliot publishes his The Indian Grammar, a book written to assist in conversion work among the Indians. Described as "some bones and ribs preparation for such a work", Eliot intended his Grammar for missionaries wishing to learn the dialect spoken by the Massachusett Indians.
1667 - The first missionary to attempt to reach the Huaorani (or Aucas), Jesuit Pedro Suarez, is slain with spears 
1668 - In a letter from his post in Canada, French missionary Jacques Bruyas laments his ignorance of the Oneida language: "What can a man do who does not understand their language, and who is not understood when he speaks. As yet, I do nothing but stammer; nevertheless, in four months I have baptized 60 persons, among whom there are only four adults, baptized in periculo mortis. All the rest are little children."
1675 - An uprising on the islands of Micronesia leads to the death of three Christian missionaries
1676 - Kateri Tekakwitha, who became known as the Lily of the Mohawks, is baptized by a Jesuit missionary. She, along with many other Native Americans, joins a missionary settlement in Canada where a syncretistic blend of ascetic indigenous and Catholic beliefs evolves.
1681 - After arriving in New Spain, Italian Jesuit Eusebio Kino soon becomes what one writer described as "the most picturesque missionary pioneer of all North America." A bundle of evangelistic zeal, Kino was also an explorer, astronomer, cartographer, mission builder, ranchman, cattle king, and defender of the frontier 
1682 - 13 missionaries go to "remote cities" in East Siberia
1683 - Missionary Louis Hennepin returns to France after exploring Minnesota and being held captive by the Dakota to write the first book about Minnesota, Description de la Louisiane
1700 - After a Swedish missionary's sermon in Pennsylvania, one Native American posed such searching questions that the episode was reported in a 1731 history of the Swedish church in America. The interchange is noted in Benjamin Franklin's Remarks Concerning the Savages of North America (1784).
1710 - First modern Bible Society founded in Germany by Count Canstein
1711 - Jesuit Eusebio Kino, missionary explorer in southern Arizona and northern Sonora, dies suddenly in northern Mexico. Kino, who has been called "the cowboy missionary", had fought against the exploitation of Indians in Mexican silver mines.
1717 - Chen Mao writes to the Chinese Emperor about his concerns over Catholic missionaries and Western traders. He urgently requested an all-out prohibition of Catholic missionaries in the Qing provinces.
1730- Lombard, French missionary, founds a Christian village with over 600 Indians at the mouth of Kuru river in French Guiana. A Jesuit, Lombard has been called the most successful of all missionaries in converting the Indians of French Guiana
1738 - Moravian missionary George Schmidt settles in Baviaan Kloof (Valley of the Baboons) in the Riviersonderend valley of South Africa. He begins working with the Khoikhoi people, who were practically on the threshold of extinction.
1745 - David Brainerd, after preaching to Native Americans in December, wrote about the response: "They soon came in, one after another; with tears in their eyes, to know, what they should do to be saved. . . . It was an amazing season of power among them, and seemed as if God had bowed the heavens and come down ... and that God was about to convert the whole world."
1746 - From Boston a call is issued to the Christians of the New World to enter into a seven-year "Concert of Prayer" for missionary work
1748 - Roman Catholic Pedro Sanz and four other missionaries are executed, together with 14 Chinese Christians. Prior to his death, Sanz reportedly converted some of his prison guards to Christianity.
1749 - Spanish Franciscan priest Junípero Serra (1713-1784</ref> arrives in Mexico as a missionary. In 1767 he would go north to what is now California, zealously building missions and converting Native Americans.
1751 - Samuel Cooke arrives in New Jersey as a missionary for the SPGFP
1752 - Thomas Thompson, first Anglican missionary to Africa, arrives in the Gold Coast (now Ghana) 
1753 The disappearance of Erhardt and six companions leads to temporary abandonment of Moravian missionary initiatives in Labrador.
1754 - Moravian John Ettwein arrives in America from Germany as a missionary. Preaching to Native Americans and establishing missions, Ettwein will travel as far south as Georgia.
1755 - The Mahican Indian settlement at Gnadenhutten, Pa. is attacked and destroyed. Moravian missionary Johann Jacob Schmick remains with the Mahicans through exile and captivity despite almost constant threats from white neighbors. Schmick will join his Indian congregation as they seek refuge in Bethlehem, follow them as captives to Philadelphia, and remain with them after they settle in Wyalusing, Pennsylvania.
1756 - Civil unrest forces Gideon Halley away from his missionary work among the Six Nations on the Susquehanna River where he has been working for four years under the supervision of Jonathan Edwards with an appointment from the Society for Propagating the Gospel among the Indians.
1758- John Wesley baptizes two slaves, thus breaking the skin color barrier for Methodist societies
1759 - Native American Samson Occom, direct descendant of the great Mahican chief Uncas, is ordained by the Presbyterians. Occom became the first American Indian to publish works in English. These included sermons, hymns and a short autobiography.
1760 - Adam Voelker and Christian Butler arrive in Tranquebar as the first Moravian missionaries to India
1760 - Methodists first reach the West Indies.
1761 - The first Moravian missionary in Ohio, Frederick Post, settles on the north side of the Muskingum.
1763 - The Presbyterian Synod of New York orders that a collection for missions be taken. In 1767 the Synod asks that this collection be done annually.
1764 - The Moravians make a decision to expand and begin publicizing their missionary activity, particularly in the British colonies; Moravian Jens Haven makes the first of three exploratory missionary journeys to Greenland
1765 - Suriname Governor General Crommelin convinces three Moravian missionaries to work near the head waters of the Gran Rio. They settle among the Saramaka near the Senthea Creek in Granman Abini's village where they are received with mixed feelings.
1770 - John Marrant, a free black from New York City, begins ministering cross-culturally, preaching to the American Indians. By 1775 he had carried the gospel to the Cherokee and Creek Indians as well as to groups he called the Catawar and Housaw peoples.
1775 - John Crook is sent by Liverpool Methodists to the Isle of Man
1776 - Cyril Vasilyevich Suchanov builds first church among Evenks of Transbaikal (or Dauria) in (Siberia); The first baptism of an Eskimo by a Lutheran pastor takes place in Labrador.
1777 - Portuguese missionaries build a church at Hashnabad, Bangladesh
1778 - Theodore Sladich is martyred while doing missionary work to counter Islamic influence in the western Balkans
1780 - August Gottlieb Spangenberg writes An Account of the Manner in Which the Protestant Church of the Unitas Fratrum, or United Brethren, Preach the Gospel, and Carry On Their Missions Among the Heathen. Originally written in German, the book will be translated into English in 1788.
1781 - In the midst of the American Revolutionary War, the British so feared Moravian missionary David Zeisberger and his influence among the Lenape (also called Delaware) and other Native Americans that they arrested him and his assistant, John Heckewelder, charging them with treason,
1785 - Joseph White's sermon titled "On the Duty of Attempting the Propagation of the Gospel among our Mahometan and Gentoo Subjects in India" is published in the second edition of his book Sermons Containing a View of Christianity and Mahometanism, in their History, their Evidence, and their Effects. The sermon was first preached at the University of Oxford.
1790 - Prince Williams, a freed slave from South Carolina, goes to Nassau, Bahamas, where he will start Bethel Meeting House 
1791 - One hundred and twenty Korean Christians are tortured and killed for their faith. It began when Paul Yun Ji-Chung, a noble who had become a Christian, decided not to bury his mother according to traditional Confucian custom.
1792 - William Carey writes An Enquiry into the Obligations of Christians to use means for the conversion of the heathen and forms the Baptist Missionary Society to support him in establishing missionary work in India
1793 - Stephen Badin ordained in U.S. Although much of Badin's ministry was pastoral work among his own countrymen, he did some outreach among the Potawatomi Indians
1794 - Eight Russian Orthodox missionaries arrive on Kodiak Island in Alaska. Within a few months several thousand people have been baptized 
1796 - Scottish and Glasgow Missionary Societies established; In India, Johann Philipp Fabricius' translation of the Bible into Tamil is revised and published
1797 - Netherlands Missionary Society formed; The Duff, carrying 36 lay and pastoral missionaries, sails to three islands of the South Pacific; The first Christian missionary (from the London Missionary Society) visits Hiva on the Pacific island of Tahuata; he is not well received.
1798 - The Missionary Society of Connecticut is organized by the Congregationalists to take the gospel to the "heathen lands" of Vermont and Ohio. Its missionaries evangelized both European settlers and Native Americans.
1813 - The Methodists form the Wesleyan Missionary Society.
1814 - First recorded baptism of a Chinese convert, Cai Gao; American Baptist Foreign Mission Society formed; Netherlands Bible Society founded first missionaries arrive in New Zealand led by Samuel Marsden 
1836 - Plymouth Brethren begin work in Madras, India;George Müller begins his work with orphans in Bristol, England;Gossner Mission formed; Leipzig Mission Society established; Colonial Missionary Society formed; The Providence Missionary Baptist District Association is formed, one of at least six national organizations among African American Baptists whose sole objective was missionary work in Africa.
1839 - Entire Bible is published in language of Tahiti; three French missionaries martyred in Korea; English Protestant missionaries, including John Williams, murdered on Erromango (Vanuatu, South Pacific) 
1841 - Edinburgh Medical Missionary Society formed; Welsh Methodists begin working among the Khasi people of India
1842 - Methodist Missionary, Thomas Birch Freeman arrives in Badagry, Nigeria;
1842 - Church Missionary Society enters Badagry, Lagos
1842 - Gossner Mission Society receives royal sanction; Norwegian Missionary Society formed in Stavanger
1842 - Christian Mission to the Jews (CMJ) establishes Christ Church, first Anglican church in the Old City of Jerusalem
1843 - Baptist John Taylor Jones translates New Testament into the Thai language; British Society for the Propagation of the Gospel among the Jews formed
1844 - German Ludwig Krapf begins work in Mombasa on the Kenya Coast; first Young Men's Christian Association (YMCA) formed by George Williams; George Smith and Thomas McClatchie sail for China as the first two CMS missionaries to that country
1849 - Just weeks after arriving on the Melanesian island of Anatom, missionary John Geddie wrote in his journal: "In the darkness, degradation, pollution and misery that surrounds me, I will look forward in the vision of faith to the time when some of these poor islanders will unite in the triumphant song of ransomed souls, 'Unto Him that loved us, and washed us from our sins in His own blood.'"
1850 - On the occasion of Karl Gützlaff's visit to Europe, the Berlin Ladies Association for China is established in conjunction with the Berlin Missionary Association for China. Work in China will commence in 1851 with the arrival of Hermandine Neumann in Hong Kong. Rev. Thomas Valpy French, came to India in 1850, founded St. John's College, Agra, and became first Bishop of Lahore in 1877.
1851 - Allen Gardiner and six missionary colleagues die of exposure and starvation at Patagonia on the southern tip of South America because a re-supply ship from England arrives six months late.
1852 - Zenana (women) and Medical Missionary Fellowship formed in England to send out single women missionaries
1853- The Hermannsburg Missionary Society, founded in 1849 by Louis Harms, has finished training its first group of young missionaries. They are sent to Africa on a ship (the Candace) which had been built using money entirely from donations.
1854 - New York Missionary Conference, guided by Alexander Duff, ponders the question: "To what extent are we authorized by the Word of God to expect the conversion of the world to Christ?"; Henry Venn, secretary of the Church Missionary Society, sets out ideal of self-governing, self-supporting and self-propagating churches; Hudson Taylor arrives in China
1855 - Henry Steinhauer is ordained as a Canadian Methodist missionary to North American Indians and posted to Lac La Biche, Alberta. Steinhauer's missionary work had actually begun 15 years earlier in 1840 when he was assigned to Lac La Pluie to assist in translating, teaching and interpreting the Ojibwa and Cree languages.
1863 - Robert Moffat, missionary to Africa with the London Missionary Society, publishes his book Rivers of Water in a Dry Place, Being an Account of the Introduction of Christianity into South Africa, and of Mr. Moffat's Missionary Labours
1866 - Charles Haddon Spurgeon invents the Wordless Book, which is widely used in cross-cultural evangelism; Theodore Jonas Meyer (1819–1894), a converted Jew serving as a Presbyterian missionary in Italy, nurses those dying in a cholera epidemic until he himself falls prey to the disease. Barely surviving, he becomes a peacemaker between Catholics and Protestants; Robert Thomas, the first Protestant martyr in Korea, is beheaded giving a Bible to his executioner.
1868 - Robert Bruce goes to Iran, Canadian Baptist missionary Americus Timpany begins work among the Telugu people in India.
1869 - The first Methodist women's missionary magazine, The Heathen Women's Friend, begins publication. ; Riot in Yangzhou, China destroys China Inland Mission house and nearly leads to open war between Britain and China.
1870 - Clara Swain, the very first female missionary medical doctor, arrives at Bareilly, India; Orthodox Missionary Society founded 
1871 - William Sloan went to Faeroe Islands commended from a brethren assembly
1873 - Regions Beyond Missionary Union founded in London in connection with the East London Training Institute for Home and Foreign Missions; first Scripture portion (Gospel of Luke) translated into Pangasinan, a language of the Philippines, by Alfonso Lallave 
1874 - Lord Radstock's first visit to St. Petersburg, Russia, and the beginning of an evangelical awakening among the St. Petersburg nobility; Albert Sturges initiates the Interior Micronesia Mission in the Mortlock Islands under the leadership of Micronesian students from Ohwa
1876 - In September, a rusty ocean steamer arrives at a port on the Calabar River in what is now Nigeria. That part of Africa was then known as the White Man's Grave. The only woman on board that ship is 29-year-old Mary Slessor, a missionary.
1877 - James Chalmers goes to New Guinea; Presbyterians Sheldon Jackson and missionary-widow Amanda McFarland arrive at Ft. Wrangel, Alaska where they join Philip McKay (né Clah) to start missionary work. McFarland was the first white woman in Alaska, and renowned as "Alaska's Courageous Missionary."
1878 - Mass movement to Christ begins in Ongole, India
1880 - Woman missionary doctor Fanny Butler goes to India; Missionary periodical The Gospel in All Lands is launched by A. B. Simpson;Justus Henry Nelson and Fannie Bishop Capen Nelson begin 45 years of service in Belém, Pará, Brazil, establishing the first Protestant Church in Amazonia in 1883
1881 - Methodist work in Lahore, Pakistan starts in the wake of revivals under Bishop William Taylor; North Africa Mission (now Arab World Ministries) founded on work of Edward Glenny in Algeria
1881 - Home & Foreign Mission Fund (now known as Interlink) was established in Glasgow as a missionary service group for brethren missionaries from Scotland
1882 - James Gilmour, London Missionary Society missionary to Mongolia, goes home to England for a furlough. During that time he published a book: Among the Mongols. It was so well-written that one critic wrote, "Robinson Crusoe has turned missionary, lived years in Mongolia, and wrote a book about it." Concerning the author, the critic said, "If ever on earth there lived a man who kept the law of Christ, and could give proof of it, and be absolutely unconscious that he was giving it to them, it is this man whom the Mongols called 'our Gilmour.'"
1886 - Student Volunteer Movement launched as 100 university and seminary students at Moody's conference grounds at Mount Hermon, Massachusetts, sign the Princeton Pledge which says: "I purpose, God willing, to become a foreign missionary."
1889 - Missionary linguist and folklorist Paul Olaf Bodding arrives in India, Santhal Parganas, and continues the work among the Santals started by Skrefsrud and Børresen in 1867; North Africa Mission enters Tripoli as first Protestant mission in Libya
1890 - Central American Mission founded by C. I. Scofield, editor of the Scofield Reference Bible; Methodist Charles Gabriel writes missionary song "Send the Light"; John Livingston Nevius of China visits Korea to outline his strategy for missions: 1) Each believer should be a productive member of society and active in sharing his faith; 2) The church in Korea should be distinctly Korean and free of foreign control; 3) The leaders of the Korean church will be selected and trained from its members; 4) Church buildings will be built by Koreans with their own resources
1891 - Samuel Zwemer goes to Arabia; Helen Chapman sails for the Congo (Zaire). She married a Danish missionary, William Rasmussen, whom she met during the voyage.
1898 - Theresa Huntington leaves her New England home for the Middle East. For seven years she will work as an American Board missionary in Elazığ (Kharput) in the Ottoman Empire. Her letters home will be published in a book titled Great Need over the Water ; Archibald Reekie of the Canadian Baptist Ministries arrives in Oruro as the first Protestant missionary to Bolivia. The work of Canadian Baptists led to the guarantee of freedom of religion in Bolivia in 1905.
1901 - Nazarene John Diaz goes to Cape Verde Islands; Maude Cary sails for Morocco; Oriental Missionary Society founded by Charles Cowman (his wife is the compiler of popular devotional book Streams in the Desert); Missionary James Chalmers killed and eaten by cannibals in Papua New Guinea
1907 - Massive revival meetings in Korea; Harmon Schmelzenbach sails for Africa; Presbyterians and Methodists open Union Theological Seminary in Manila, Philippines; Bolivian Indian Mission founded by George Allen 
1914-1918 World War I numerous missionaries in Africa and Asia in British, French, German and Belgian colonies are expelled or detained for the duration of the war, if their nation was at war with the colonial authority
1914 - Large-scale revival movement in Uganda; C.T. Studd reports a revival movement in the Congo
1916 - Rhenish missionaries are forced to leave Ondjiva in southern Angola under pressure from the Portuguese authorities and Chief Mandume of the Kwanyama. By then, four congregations existed with a confessing membership of 800.
1917 - Interdenominational Foreign Mission Association (IFMA) founded 
1927 - Ngulhao Thomsong translates the Bible into Thadou-Kuki Language  East African revival movement (Balokole) emerges in Rwanda and moves across several other countries
1928 - Cuba Bible Institute (West Indies Mission) opens; Jerusalem Conference of International Missionary Council; foundation of Borneo Evangelical Mission by Hudson Southwell, Frank Davidson and Carey Tolley.
1929 - Christian & Missionary Alliance enters East Borneo (Indonesia) and Thailand 
1936 - With the outbreak of civil war in Spain, missionaries are forced to leave that country.
1937 - After expulsion of missionaries from Ethiopia by Italian invaders, widespread revival erupts among Protestant (SIM) churches in south;Child Evangelism Fellowship founded by Jesse Irvin Overholzer
1939-1945 - World War II numerous missionaries in Africa and Asia in British, French and Belgian colonies are expelled or detained for the duration of the war, if their nation was at war with the colonial authority
1939 - A sick missionary, Joy Ridderhof, makes a recording of gospel songs and a message and sends it into the mountains of Honduras. It is the beginning of Gospel Recordings 
1940 - Marianna Slocum begins translation work in Mexico; Military police in Japan arrest the executive officers of the Salvation Army
1947 - Conservative Baptist Foreign Mission Society begins work among the Senufo people in the Côte d'Ivoire 
1948 - Alfredo del Rosso merges his Italian Holiness Mission with the Church of the Nazarene, thus opening Nazarene work on the European continent; Southern Baptist Convention adopts program calling for the tripling of the number of missionaries (achieved by 1964</ref>
1949 - Southern Baptist Mission board opens work in Venezuela, Mary Tripp sent out by CEF Child Evangelism Fellowship to the Netherlands.
1963 - Theological Education by Extension movement launched in Guatemala by Ralph Winter and James Emery 
1964 - In separate incidents, rebels in the Congo kill missionaries Paul Carlson, Phyllis Rine and Irene Ferrel as well as brutalizing missionary doctor Helen Roseveare; Carlson is featured on December 4 Time magazine cover; Hans von Staden of the Dorothea Mission proposes to Patrick Johnstone that he write the book now titled Operation World
1972 - American Society of Missiology founded with journal Missiology
1973 - Services by Billy Graham attract four and a half million people in six cities of Korea; first All-Asa Mission Consultation convenes in Seoul, Korea with 25 delegates from 14 countries;Mission to the World is founded in Georgia
1982 - Story on "The New Missionary" makes December 27 cover of Time magazine; Andes Evangelical Mission (formerly Bolivian Indian Mission</ref> merges into SIM (formerly Sudan Interior Mission</ref>
1983 - Missionary Athletes International, a global soccer ministry, founded by Tim Conrad
1984 - Founding of The Mission Society for United Methodists, a voluntary missionary sending agency within the United Methodist Church; rebranded in 2006 to The Mission Society; Founding of STEM (Short Term Evangelical Mission teams) ministry by Roger Petersen signals the rising importance of Short-term missions groups
1985 - Howard Foltz founds Accelerating International Mission Strategies (AIMS)
1999 - Trans World Radio goes on the air from Grigoriopol (Moldova) using a 1-million-watt AM transmitter; Veteran Australian missionary Graham Stuart Staines and his two sons are burned alive by Hindu extremists as they are sleeping in a car in eastern India.
2000 - Asia College of Ministry (ACOM), a ministry of Asia Evangelistic Fellowship (AEF), was launched by Jonathan James, to train national missionaries in Asia.
2001 - New Tribes Missionaries Martin and Gracia Burnham are kidnapped in the Philippines by Muslim terrorist group; Baptist missionary Roni Bowers and her infant daughter are killed when a Peruvian Air Force jet fires on their small float-plane. Though severely wounded in both legs, missionary pilot Kevin Donaldson landed the burning plane on the Amazon River.
2003 - Publication of Back To Jerusalem Called to Complete the Great Commission - Three Chinese Church Leaders with Paul Hattaway brings Chinese and Korean mission movement to forefront; Coptic priest Fr. Zakaria Botros begins his television and internet mission to Muslims in North Africa, the Middle East, Central Asia, and western countries, resulting in thousands of conversions.
2006 - Abdul Rahman, an Afghan Christian convert, is forced out of Afghanistan by local Muslim leaders and exiled to Italy. Missionary Vijay Kumar is publicly stoned by Hindu extremists for Christian preaching.
2007 - Kriol Bible completed, the first translation of the entire Bible into an Australian indigenous language Youth Missions International (Washington) (YMI) was founded by Brian Hughes to train churches and teens in the United States to do evangelism locally, regionally, and internationally.
^Thwaites, Reuben Gold. The Revolution on the Upper Ohio, 1775-1777: Compiled from the Draper Manuscripts in the Library of the Wisconsin Historical Society. Genealogical Publishing Company, 2002, p. 45.
^White, Ann "Counting the Cost of Faith: America's Early Female Missionaries" Church History, Vol 57, No. 1 (Mar 1988), p. 22; Brackney, William H The A to Z of Baptists Lanham, MD: Scarecrow Press, 2009, p. 605
Laroutette, Kenneth Scott. A History of Christianity, 2 vol 1975
Latourette, Kenneth Scott. A History of the Expansion of Christianity, 7 volumes, (1938–45), the most detailed scholarly history
Moreau, A. Scott, David Burnett, Charles Edward van Engen and Harold A. Netland. Evangelical Dictionary of World Missions, Baker Book House Company, 2000
Neill, Stephen. A History of Christian Missions. Penguin Books, 1986
Newcomb, Harvey. A Cyclopedia of Missions: Containing a Comprehensive View of Missionary Operations Throughout the World : with Geographical Descriptions, and Accounts of the Social, Moral, and Religious Condition of the People (1860) 792 pages complete text online
Olson, C. Gordon. What in the World is God Doing? Global Gospel Publishers, 2003
Parker, J. Fred. Mission to the World. Nazarene Publishing House, 1988
Pocock, Michael, Gailyn Van Rheenen, Douglas McConnell. The Changing Face of World Missions: Engaging Contemporary Issues And Trends (2005); 391 pages
Tejirian, Eleanor H., and Reeva Spector Simon, eds. Conflict, Conquest, and Conversion: Two Thousand Years of Christian Missions in the Middle East (Columbia University Press; 2012) 280 pages; focus on the 19th and 20th centuries.
Tucker, Ruth (2004), From Jerusalem to Irian Jaya
Tucker, Ruth (1988), Guardians of the Great Commission
Walker, Williston. A History of the Christian Church. 1959