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2-Fluoromethamphetamine

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This is an old revision of this page, as edited by Gettinglit (talk | contribs) at 06:22, 25 September 2022 (2-FMA is not scheduled in the USA. It can be prosecutor if it's found to be marketed for human consumption under the federal analog act but that does not mean the substance itself is a schedule 1.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Not to be confused with 2-Fluoroamphetamine.

2-Fluoromethamphetamine (2-FMA) is a stimulant drug of the amphetamine family which has been used as a designer drug .[1][2][3] 2-FMA is commonly compared to lisdexamfetamine (Vyvanse), and dextroamphetamine due to its efficacy as a study or productivity aid. 2-FMA is purported to produce somewhat less euphoria than comparable amphetamines, likely due to its main mechanism of action consisting of norepinephrine reuptake inhibition.[4][citation needed]

2-Fluoromethamphetamine
Ball-and-stick model of the 2-fluoromethamphetamine molecule
Clinical data
Routes of
administration		By mouth
Legal status
Legal status
  • CA: Schedule I[5]
  • DE: Anlage I (Authorized scientific use only)
  • UK: Class A
  • US: Unscheduled
Identifiers
  • (RS)-1-(2-Fluorophenyl)-N-methylpropan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H14FN
Molar mass167.227 g·mol−1
3D model (JSmol)
  • CC(CC1=CC=CC=C1F)NC
  • InChI=1S/C10H14FN/c1-8(12-2)7-9-5-3-4-6-10(9)11/h3-6,8,12H,7H2,1-2H3 checkY
  • Key:XNWIKJYFOIDUGD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Chemistry

2-Fluoromethamphetamine is fluorinated analogue of methamphetamine, and is a regioisomer of 3-FMA and 4-FMA.

It does not activate the serotonin receptors, including 5-HT2A,[4] unlike most stimulant drugs of the amphetamine family.

Legal status

Canada

As of 1996, 2-FMA is a controlled substance in Canada, due to being an analog of methamphetamine.[5]

China

As of October 2015, 2-FMA is a controlled substance in China.[6]

Germany

As of 13 December 2014, 2-FMA is a controlled substance in Germany.[7] It is controlled under Anlage I BtMG (Narcotics Act, Schedule I).[8] Substances controlled under Anlage I BtMG are illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license. Violations of the law are punishable by a fine or imprisonment for up to five years.[9]

Ukraine

As of July 2019, 2-FMA is a controlled substance in Ukraine (considered a narcotic).[10]

United States

As a close analog of scheduled controlled substance,[1] sale or possession of 2-FMA could be potentially be prosecuted under the Federal Analogue Act.[11]

See also

References

  1. ^ a b Rösner P, Quednow B, Girreser U, Junge T (March 2005). "Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs)". Forensic Science International. 148 (2–3): 143–56. doi:10.1016/j.forsciint.2004.05.003. PMID 15639609.
  2. ^ Camilleri A, Johnston MR, Brennan M, Davis S, Caldicott DG (April 2010). "Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone". Forensic Science International. 197 (1–3): 59–66. doi:10.1016/j.forsciint.2009.12.048. PMID 20074881.
  3. ^ Ishii, Ayumu; Sato, Kazuki; Kusakabe, Kosuke; Kato, Noriyuki; Wada, Takeshi (May 2022). "Identification and Quantitative Analysis of 2-Fluoro Methamphetamine and its Metabolites in Human Urine". Journal of Analytical Toxicology. doi:10.1093/jat/bkac026. ISSN 0146-4760. PMID 35562170.
  4. ^ a b Åstrand, Anna; Guerrieri, Davide; Vikingsson, Svante; Kronstrand, Robert; Green, Henrik (23 March 2020). "In vitro characterization of new psychoactive substances at the μ-opioid, CB1, 5HT1A, and 5-HT2A receptors—On-target receptor potency and efficacy, and off-target effects". Forensic Science International. 317: 110553. doi:10.1016/j.forsciint.2020.110553.
  5. ^ a b Branch, Legislative Services (31 March 2022). "Consolidated federal laws of Canada, Controlled Drugs and Substances Act". laws-lois.justice.gc.ca. Archived from the original on 11 June 2022. Retrieved 11 August 2022.
  6. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  7. ^ Bundesgesetzblatt. "Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften – Vom 5. Dezember 2014" (in German). Bundesanzeiger-Verlags-GmbH. Retrieved 6 April 2022.
  8. ^ Bundesministerium der Justiz. "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz – BtMG) Anlage I (zu § 1 Abs. 1) (nicht verkehrsfähige Betäubungsmittel)" (in German). Retrieved 6 April 2022.
  9. ^ Bundesministerium der Justiz. "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz – BtMG) § 29 Straftaten" (in German). Retrieved 6 April 2022.
  10. ^ "Про внесення змін до Закону України "Про обіг в Україні наркотичних засобів, психотропних речовин, їх аналогів і прекурсорів"" (in Ukrainian). Verkhovna Rada of Ukraine. 23 July 2019. Archived from the original on 6 September 2021. Retrieved 6 September 2021. {{cite web}}: |archive-date= / |archive-url= timestamp mismatch; 5 September 2021 suggested (help)
  11. ^ "Federal Controlled Substance Analogue Act Summary". Erowid Analog Law Vault.


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