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2C-T-2, or 2,5-dimethoxy-4-ethylthiophenethylamine is a psychedelic and entactogenic phenethylamine of the 2C family. It was first synthesized in 1981 by Alexander Shulgin. The drug has structural and pharmacodynamic properties similar to the drug 2C-T-7 ('Blue Mystic').
In Alexander Shulgin's book PiHKAL, the dosage range is listed as 12 to 25 mg. According to Erowid a threshold dose would be 5 mg, a light dose would range from 8–15 mg, a common dose is 15–22 mg and a strong dose would be considered to be 20–40 mg.
Effects are similar to the related 2C-T-7, but 2C-T-2 is said to produce more of a body load and other reactions which can be unpleasant, reported effects being reddening of the face and warm flushes. It can also be very nauseating while coming up, some users report a period of restlessness during the come up and feeling cold. There have been no reported deaths from 2C-T-2, unlike 2C-T-7, and the psychedelic effects have been much milder. The onset usually starts after an hour of ingestion and rises for about two hours until the user hits the plateau. Insufflated doses reach a peak much faster and have been compared to the effect of ketamine on the body.
Hallucinations similar to those created by LSD and other serotonergic psychedelics are very prominent on typical 2C-T-2 doses. The trip is often described as being similar to LSD due to the serotonergic effects and hallucinations. Some users describe "beautiful" visuals, similar to 2C-T-7, which has coined its street name "Rosy". In some aspects the effect is similar to other phenethylamines like MDMA (users sometimes have euphoric rushes); however, unlike MDMA, 2C-T-2 is a strong psychedelic, and its effects can be unpredictable, even for "experienced" users.
2C-T-2 can be just as powerful as LSD and other hallucinogens. Due to the particular body load effect of this substance it is significantly different than most popular hallucinogens though its capability to produce a bad trip is still present. Effects can last up to 16 hours from dosing.
The mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
There are no known reports of neurotoxicity, but very little scientific knowledge exists for 2C-T-2.
Drug prohibition laws
As of October 2015 2C-T-2 is a controlled substance in China.
The Netherlands became the first country in the world to ban 2C-T-2, and classify it as a hard drug, by law. In April, 1999, 2C-T-2 became a list I drug of the Opium Law.
Schedule I in Sweden. 2C-T-2 was first classified as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of April 1, 1999 under SFS 1999:58 that made it illegal to sell or possess.
2C-T-2 is specifically listed as a schedule I substance under SEC. 1152 of S.3187: Food and Drug Administration Safety and Innovation Act of 2012.
2C-T-2 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.
- Theobald, DS; R Staack; M Puetz; HH Mauer (September 2005). "New designer drug 2,5-dimethoxy-4-ethylthio-β-phenethylamine (2C-T-2): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry". Journal of Mass Spectrometry 40 (9): 1157–1172. doi:10.1002/jms.890. PMID 16041763.
- Last Argentina Controlled Drugs List
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534