Fludorex
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Chemical compound
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Formula | C11H14F3NO |
Molar mass | 233.230 g·mol−1 |
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Fludorex is a stimulant anorexic agent of the phenethylamine chemical class.[1]
Synthesis
Grignard reaction between 3-Bromobenzotrifluoride [401-78-5] (1) and 1,2-dibromo-1-methoxyethane, CID:13226400 (2) leads to 1-(2-bromo-1-methoxyethyl)-3-(trifluoromethyl)benzene, CID:10589008 (3). The reaction with methylamine gives fludorex (4).
See also
The benzylamine is called SK&F 39728-A
References
- ^ Beregi SL, Duhault J (1977). "Structure-anorectic activity relationships in substituted phenethylamines". Arzneimittel-Forschung. 27 (1): 116–8. PMID 576809.
- ^ NL6608794 idem John A Faust, Melville Sahyun, U.S. patent 3,459,803 (1969 to Melville Sahyun, Sahyun Lab).
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