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PTPN6

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PTPN6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, protein tyrosine phosphatase, non-receptor type 6, protein tyrosine phosphatase non-receptor type 6
External IDsOMIM: 176883; MGI: 96055; HomoloGene: 56589; GeneCards: PTPN6; OMA:PTPN6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5777

15170

Ensembl

ENSG00000111679

ENSMUSG00000004266

UniProt

P29350

P29351

RefSeq (mRNA)

NM_002831
NM_080548
NM_080549

NM_001077705
NM_013545

RefSeq (protein)

NP_002822
NP_536858
NP_536859

NP_001071173
NP_038573

Location (UCSC)Chr 12: 6.95 – 6.96 MbChr 6: 124.7 – 124.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.[5]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling, (e.g., the LYN-CD22-SHP-1 pathway). Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.[6]

Expression

SHP-1 gene has two promoters: P-1, active in epithelial cells, and P-2, active in hemopoietic cells. In addition the expression of SHP-1 is low in epithelial cells and high in hemopoietic cells. SHP-1 level in epithelial cells increases and in hematopoietic cells decreases in cancer.[7]

Interactions

PTPN6 has been shown to interact with:

References

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  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004266 – Ensembl, May 2017
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  24. ^ Kon-Kozlowski M, Pani G, Pawson T, Siminovitch KA (February 1996). "The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells". J. Biol. Chem. 271 (7): 3856–62. doi:10.1074/jbc.271.7.3856. PMID 8632004.
  25. ^ Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C (May 2002). "Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement". Biochem. J. 363 (Pt 3): 717–25. doi:10.1042/0264-6021:3630717. PMC 1222524. PMID 11964172.
  26. ^ Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (September 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". J. Biol. Chem. 277 (39): 36878–88. doi:10.1074/jbc.M203917200. PMID 12145285.
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