Homeobox A10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
HOXA10
Identifiers
Aliases HOXA10, HOX1, HOX1.8, HOX1H, PL, Homeobox A10
External IDs MGI: 96171 HomoloGene: 7365 GeneCards: 3206
RNA expression pattern
PBB GE HOXA10 213147 at tn.png

PBB GE HOXA10 213150 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018951
NM_153715

NM_001122950
NM_008263

RefSeq (protein)

NP_061824.3

NP_001116422.1
NP_032289.2

Location (UCSC) Chr 7: 27.17 – 27.18 Mb Chr 6: 52.23 – 52.24 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.[1][2][3]

Function[edit]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.[3]

Interactions[edit]

Homeobox A10 has been shown to interact with PTPN6.[4]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXA10 homeobox A10". 
  4. ^ Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (Sep 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry 277 (39): 36878–88. doi:10.1074/jbc.M203917200. PMID 12145285. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.