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Cloxestradiol acetate Trade names Genovul Other names 1-{[(17β)-3-Acetoxyestra-1,3,5(10)-trien-17-yl]oxy}-2,2,2-trichloroethyl acetate Pregnancy category
[(8R ,9S ,13S ,14S ,17S )-17-(1-Acetyloxy-2,2,2-trichloroethoxy)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a ]phenanthren-3-yl] acetate
CAS Number PubChem CID ChemSpider CompTox Dashboard (EPA ) Formula C 24 H 29 Cl 3 O 5 Molar mass 503.84306 g/mol g·mol−1 3D model (JSmol )
CC(=O)OC1=CC2=C(C=C1)C3CCC4(C(C3CC2)CCC4OC(C(Cl)(Cl)Cl)OC(=O)C)C
InChI=1S/C24H29Cl3O5/c1-13(28)30-16-5-7-17-15(12-16)4-6-19-18(17)10-11-23(3)20(19)8-9-21(23)32-22(24(25,26)27)31-14(2)29/h5,7,12,18-22H,4,6,8-11H2,1-3H3/t18-,19-,20+,21+,22?,23+/m1/s1
Key:UEVLJPRROXDIPO-CUFSGNDSSA-N
Cloxestradiol acetate (brand name Genovul ) is a synthetic , steroidal estrogen derived from estradiol .[ 1] It is the O ,O -diacetate form of cloxestradiol , which, in contrast to cloxestradiol acetate, was never marketed.[ 1]
References
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Estrogens
ER Tooltip Estrogen receptor agonists
Steroidal: Alfatradiol
Certain androgens /anabolic steroids (e.g., testosterone , testosterone esters , methyltestosterone , metandienone , nandrolone esters ) (via estrogenic metabolites)
Certain progestins (e.g., norethisterone , noretynodrel , etynodiol diacetate , tibolone )
Clomestrone
Cloxestradiol acetate
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Conjugated estrogens
Epiestriol
Epimestrol
Esterified estrogens
Estetrol †
Estradiol
Estradiol esters (e.g., estradiol acetate , estradiol benzoate , estradiol cypionate , estradiol enanthate , estradiol undecylate , estradiol valerate , polyestradiol phosphate , estradiol ester mixtures (Climacteron ))
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ER Tooltip Estrogen receptor antagonists (incl. SERMs Tooltip selective estrogen receptor modulators /SERDs Tooltip selective estrogen receptor downregulators )Aromatase inhibitors Antigonadotropins
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3α-Hydroxytibolone
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4-Androstenedione
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7α-Methylestradiol
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8,9-Dehydroestradiol
8,9-Dehydroestrone
8β-VE2
10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)
11β-Chloromethylestradiol
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15α-Hydroxyestradiol
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17α-Ethynyl-3α-androstanediol
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ent -Estradiol
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Agonists Antagonists Unknown