EIF4H

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EIF4H
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4H, WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H
External IDsOMIM: 603431 MGI: 1341822 HomoloGene: 32536 GeneCards: EIF4H
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022170
NM_031992

NM_033561
NM_001312867

RefSeq (protein)

NP_071496
NP_114381

NP_001299796
NP_291039

Location (UCSC)Chr 7: 74.17 – 74.2 MbChr 5: 134.65 – 134.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.[5][6][7]

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EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106682Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040731Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC (Apr 1998). "Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H". J Biol Chem. 273 (13): 7579–87. doi:10.1074/jbc.273.13.7579. PMID 9516461.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Doepker RC, Hsu WL, Saffran HA, Smiley JR (Apr 2004). "Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H". J Virol. 78 (9): 4684–99. doi:10.1128/JVI.78.9.4684-4699.2004. PMC 387725. PMID 15078951.
  7. ^ "Entrez Gene: EIF4H eukaryotic translation initiation factor 4H".
  8. ^ "Early discovery may aid search for anti-aging drugs". 2010.

Further reading

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