MRPS16

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MRPS16
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS16, COXPD2, MRP-S16, RPMS16, CGI-132, mitochondrial ribosomal protein S16
External IDs MGI: 1913492 HomoloGene: 9370 GeneCards: MRPS16
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016065

NM_025440

RefSeq (protein)

NP_057149

NP_079716.1
NP_079716

Location (UCSC) Chr 10: 73.25 – 73.25 Mb Chr 14: 20.39 – 20.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S16, mitochondrial is a protein that in humans is encoded by the MRPS16 gene.[3][4]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described.[4]

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