MRPS28

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MRPS28
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS28, MRP-S28, MRP-S35, MRPS35, HSPC007, mitochondrial ribosomal protein S28
External IDsOMIM: 611990 MGI: 1913480 HomoloGene: 8519 GeneCards: MRPS28
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for MRPS28
Genomic location for MRPS28
Band8q21.13Start79,918,717 bp[1]
End80,030,289 bp[1]
RNA expression pattern
PBB GE MRPS28 219819 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014018

NM_025434

RefSeq (protein)

NP_054737

NP_079710

Location (UCSC)Chr 8: 79.92 – 80.03 MbChr 3: 8.8 – 8.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28 gene.[5][6][7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147586 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040269 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  7. ^ a b "Entrez Gene: MRPS28 mitochondrial ribosomal protein S28".

Further reading[edit]