MRPS21

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MRPS21
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS21, MRP-S21, RPMS21, MDS016, mitochondrial ribosomal protein S21
External IDs MGI: 1913542 HomoloGene: 45365 GeneCards: MRPS21
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031901
NM_018997

NM_078479

RefSeq (protein)

NP_061870
NP_114107

NP_510964.1
NP_510964

Location (UCSC) Chr 1: 150.29 – 150.31 Mb Chr 3: 95.86 – 95.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S21, mitochondrial is a protein that in humans is encoded by the MRPS21 gene.[3][4]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist protein synthesis within the mitochondrion.[3] Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family.[4] Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q.[5] Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634. 
  4. ^ a b Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (June 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123. 
  5. ^ Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105. 
  6. ^ "Entrez Gene: MRPS21 mitochondrial ribosomal protein S21". 

Further reading[edit]

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928Freely accessible. PMID 15489334.