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ER-X is a membrane-associated receptor that is bound and activated by 17α-estradiol and 17β-estradiol and is a putative membrane estrogen receptor (mER).[1][2][3] It shows sequence homology with ERα and ERβ and activates the MAPK/ERK pathway.[3] The receptor is insensitive to the antiestrogen ICI-182,780 (fulvestrant).[3]

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  1. ^ Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly ES, Nethrapalli IS, Tinnikov AA (2002). "ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury". J. Neurosci. 22 (19): 8391–401. doi:10.1523/JNEUROSCI.22-19-08391.2002. PMC 6757764. PMID 12351713.
  2. ^ Soltysik K, Czekaj P (2013). "Membrane estrogen receptors - is it an alternative way of estrogen action?". J. Physiol. Pharmacol. 64 (2): 129–42. PMID 23756388.
  3. ^ a b c Roepke TA, Ronnekleiv OK, Kelly MJ (2011). "Physiological consequences of membrane-initiated estrogen signaling in the brain". Front Biosci. 16: 1560–73. doi:10.2741/3805. PMC 3094271. PMID 21196248.