Phenbenzamine

Phenbenzamine
Clinical data
Trade names	Antergan
Identifiers
	IUPAC name N-(2-Dimethylaminoethyl)-N-benzylaniline;
PubChem CID	13751;
ChemSpider	13155 ;
CompTox Dashboard (EPA)	DTXSID3043863 ;
Chemical and physical data
Formula	C17H22N2
Molar mass	254.36998 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCN(Cc1ccccc1)c2ccccc2;
	InChI InChI=InChI=1S/C17H22N2/c1-18(2)13-14-19(17-11-7-4-8-12-17)15-16-9-5-3-6-10-16/h3-12H,13-15H2,1-2H3 ; Key:CHOBRHHOYQKCOU-UHFFFAOYSA-N ;

Phenbenzamine (Antergan) is an antihistamine with anticholinergic properties.^[1]

Synthesis

References

^ http://www.britannica.com/EBchecked/topic/455484/phenbenzamine
^ L. P. Kyrides and F. B. Zienty, U.S. patent 2,634,293 (1953).
^ Kaye, Irving Allan; Parris, Chester L.; Weiner, Nathan (1953). "A Novel N-Alkylation Reaction". Journal of the American Chemical Society. 75 (3): 744–745. doi:10.1021/ja01099a508. ISSN 0002-7863.

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[1] ttp://www.britannica.com/EBchecked/topic/455484/phenbenzamine

[2] L. P. Kyrides and F. B. Zienty, U.S. patent 2,634,293 (1953).

[KayeParris1953-3] Kaye, Irving Allan; Parris, Chester L.; Weiner, Nathan (1953). "A Novel N-Alkylation Reaction". Journal of the American Chemical Society. 75 (3): 744–745. doi:10.1021/ja01099a508. ISSN 0002-7863.

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v t e Antihistamines (R06)
Benzimidazoles (*)	Astemizole Azelastine Bilastine Emedastine Mizolastine Talastine
Diarylmethanes	Diarylmethoxyalkylamines: Bromazine (bromodiphenhydramine) Carbinoxamine Chlorphenoxamine Clemastine Diphenhydramine (+naproxen) Diphenylpyraline Doxylamine Ebastine Orphenadrine Diphenylmethanolpiperidines: Fexofenadine Terfenadine Diphenylmethylpiperazines: Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Etodroxizine Hydroxyzine Meclizine Oxatomide Phenylpyridinylpropanamines: Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Pheniramine Others: Acrivastine Bamipine Dimetindene Phenyltoloxamine Pyrrobutamine Quifenadine Triprolidine
Ethylenediamines	Antazoline Chloropyramine Histapyrrodine Mepyramine (pyrilamine) Methapyrilene Phenbenzamine Thenalidine Tripelennamine (pyribenzamine)
Tricyclics	Dibenzocycloheptenes: Antidepressants (e.g., amitriptyline) Azatadine Cyproheptadine Deptropine Desloratadine Ketotifen Loratadine Rupatadine Phenothiazines: Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Others: Antidepressants (e.g., doxepin, mirtazapine, trimipramine) Epinastine Latrepirdine Mebhydrolin Olopatadine Perlapine Phenindamine Pimethixene
Others	Phenylpiperazines: Antidepressants (e.g., trazodone) Phenbenzamine
For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Doxepin Isothipendyl Mepyramine (pyrilamine) Promethazine

Synthesis

See also

References