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Calcium/calmodulin-dependent protein kinase II beta
Protein CAMK2B PDB 2ux0.png
PDB rendering based on 2ux0.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM607707 MGI88257 HomoloGene111050 ChEMBL: 4121 GeneCards: CAMK2B Gene
EC number
RNA expression pattern
PBB GE CAMK2B 209956 s at tn.png
PBB GE CAMK2B 210404 x at tn.png
PBB GE CAMK2B 211483 x at tn.png
More reference expression data
Species Human Mouse
Entrez 816 12323
Ensembl ENSG00000058404 ENSMUSG00000057897
UniProt Q13554 P28652
RefSeq (mRNA) NM_001220 NM_001174053
RefSeq (protein) NP_001211 NP_001167524
Location (UCSC) Chr 7:
44.26 – 44.37 Mb
Chr 11:
5.97 – 6.07 Mb
PubMed search [1] [2]

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.[1]


CAMK2B has been shown to interact with Actinin alpha 4.[2]


  1. ^ "Entrez Gene: CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta". 
  2. ^ Walikonis, R S; Oguni A; Khorosheva E M; Jeng C J; Asuncion F J; Kennedy M B (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. (United States) 21 (2): 423–33. PMID 11160423. 

Further reading[edit]