TNNC2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Troponin C type 2 (fast)
PBB Protein TNNI2 image.jpg
PDB rendering based on 1a2x.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol TNNC2
External IDs OMIM191039 MGI98780 HomoloGene55727 GeneCards: TNNC2 Gene
RNA expression pattern
PBB GE TNNC2 205388 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7125 21925
Ensembl ENSG00000101470 ENSMUSG00000017300
UniProt P02585 P20801
RefSeq (mRNA) NM_003279 NM_009394
RefSeq (protein) NP_003270 NP_033420
Location (UCSC) Chr 20:
44.45 – 44.46 Mb
Chr 2:
164.78 – 164.78 Mb
PubMed search [1] [2]

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.[1][2]

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.[2]

References[edit]

  1. ^ Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem 265 (21): 12520–8. PMID 2373703. 
  2. ^ a b "Entrez Gene: TNNC2 troponin C type 2 (fast)". 

Further reading[edit]