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Calcium/calmodulin-dependent protein kinase I
Protein CAMK1 PDB 1a06.png
PDB rendering based on 1a06.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CAMK1 ; CAMKI
External IDs OMIM604998 MGI1098535 HomoloGene117458 IUPHAR: 1952 ChEMBL: 2493 GeneCards: CAMK1 Gene
EC number
RNA expression pattern
PBB GE CAMK1 204392 at tn.png
More reference expression data
Species Human Mouse
Entrez 8536 52163
Ensembl ENSG00000134072 ENSMUSG00000030272
UniProt Q14012 Q91YS8
RefSeq (mRNA) NM_003656 NM_133926
RefSeq (protein) NP_003647 NP_598687
Location (UCSC) Chr 3:
9.8 – 9.81 Mb
Chr 6:
113.33 – 113.34 Mb
PubMed search [1] [2]

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.[1][2]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[2]


Further reading[edit]

  • Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. PMID 1375933. 
  • Yokokura H, Picciotto MR, Nairn AC, Hidaka H (1995). "The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains". J. Biol. Chem. 270 (40): 23851–9. doi:10.1074/jbc.270.40.23851. PMID 7559563. 
  • Liu F, Thompson MA, Wagner S et al. (1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation". J. Biol. Chem. 268 (9): 6714–20. PMID 8384217. 
  • Chin D, Winkler KE, Means AR (1998). "Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I". J. Biol. Chem. 272 (50): 31235–40. doi:10.1074/jbc.272.50.31235. PMID 9395448. 
  • Hsu LS, Tsou AP, Chi CW et al. (1998). "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase". J. Biomed. Sci. 5 (2): 141–9. doi:10.1007/bf02258368. PMID 9662074. 
  • Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275. 
  • Anderson KA, Means RL, Huang QH et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657. 
  • Matsushita M, Nairn AC (1999). "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase". J. Biol. Chem. 274 (15): 10086–93. doi:10.1074/jbc.274.15.10086. PMID 10187789. 
  • Hayashi Y, Nishio M, Naito Y et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690. 
  • Hosaka M, Hammer RE, Südhof TC (1999). "A phospho-switch controls the dynamic association of synapsins with synaptic vesicles". Neuron 24 (2): 377–87. doi:10.1016/S0896-6273(00)80851-X. PMID 10571231. 
  • Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031. 
  • McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature 408 (6808): 106–11. doi:10.1038/35040593. PMID 11081517. 
  • McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMC 18930. PMID 11114197. 
  • Hsu LS, Chen GD, Lee LS et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482. 
  • Condon JC, Pezzi V, Drummond BM et al. (2002). "Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase". Endocrinology 143 (9): 3651–7. doi:10.1210/en.2001-211359. PMID 12193581. 
  • Sakurada K, Kato H, Nagumo H et al. (2003). "Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin". J. Biol. Chem. 277 (47): 45473–9. doi:10.1074/jbc.M206673200. PMID 12237306. 
  • Clapperton JA, Martin SR, Smerdon SJ et al. (2003). "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism". Biochemistry 41 (50): 14669–79. doi:10.1021/bi026660t. PMID 12475216. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Izmailova E, Bertley FM, Huang Q et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.