Ethocybin

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Ethocybin
Ethocybin.png
Systematic (IUPAC) name
Phosphoric acid mono-[3-(2-diethylamino-ethyl)-1H-indol-4-yl] ester
Clinical data
Legal status
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Identifiers
CAS number 60480-02-6 YesY
ATC code None
ChemSpider 21106438 YesY
Synonyms 4-Phosphoryloxy-N,N-diethyltryptamine; CEY-39; 4-phosphoryloxy-DET; 4-PO-DET
Chemical data
Formula C14H21N2O4P 
Mol. mass 312.30 g/mol
 YesY (what is this?)  (verify)

Ethocybin (CEY-19; 4-phosphoryloxy-DET; 4-PO-DET) is a homologue of the mushroom alkaloid psilocybin, and a semi-synthetic psychedelic alkaloid of the tryptamine family. Effects of ethocybin are comparable to those of a shorter LSD or psilocybin, although intensity and duration vary depending on dosage, individual physiology, and set and setting.[citation needed]

Chemistry[edit]

As with psilocybin and psilocin, ethocybin is a prodrug that is converted into the pharmacologically active compound ethocin in the body by dephosphorylation.[citation needed] This chemical reaction takes place under strongly acidic conditions or enzymatically by phosphatases in the body.

Albert Hofmann was the first to produce this chemical, soon after his discovery of psilocin and psilocybin.[1] It was sold under the code name CEY-39.

Pharmacology[edit]

As with psilocybin, ethocybin is rapidly dephosphorylated in the body to 4-HO-DET which then acts as a partial agonist at the 5-HT2A serotonin receptor in the brain where it mimics the effects of serotonin (5-HT).[citation needed]

Medicine[edit]

Ethocybin has been studied as a treatment for several disorders since the early 1960s, and numerous papers are devoted to this material.[citation needed] Its short-lived action was considered a virtue. A 2010 Study showed that Ethocybin helped with bipolar.

Effects[edit]

Ethocybin is absorbed through the lining of the mouth and stomach. Effects begin 20-45 minutes after ingestion, and last from 2-4 hours depending on dose, species, and individual metabolism.[citation needed] The effects are somewhat shorter compared to psilocybin.

Pharmacology[edit]

Ethocybin is probably metabolized mostly in the liver where it becomes ethocin, but is also broken down by the enzyme monoamine oxidase.[citation needed]

Mental and physical tolerance to psilocybin builds and dissipates quickly. Taking ethocybin more than three or four times in a week (especially two days in a row) can result in diminished effects. Tolerance dissipates after a few days, so frequent users often keep doses spaced five to seven days apart to avoid the effect.

Legality[edit]

Ethocybin is not controlled in the USA, but possession or sale may be considered illegal under the Federal Analog Act.

References[edit]

  1. ^ US patent 3075992, Hofmann, Albert; Troxler, Franz., "Esters of indoles", issued 1963-1-29