COVIran Barekat
| File:COVIran Barakat VACCINE.jpg | |
| Vaccine description | |
|---|---|
| Target | SARS-CoV-2 |
| Vaccine type | Inactivated |
| Clinical data | |
| Routes of administration | Intramuscular |
| ATC code |
|
COVIran Barakat is a COVID-19 vaccine candidate developed by Iranian state-owned Shifa Pharmed Industrial Group. It has successfully been tested on animals and has been approved by the Iran Food and Drug Administration for testing on humans.[1][2][3] Phase 2/3 (II/III) clinical trial has began on March 13 2021[4] and the first participants have been inoculated on March 29.[5]
Technology
On 29 December, human trials of Iran's first domestic COVID-19 vaccine candidate were started. The mechanism of production of this vaccine is based on the inactivated vaccine. In other words, "it is made of a coronavirus that has been weakened or killed by chemicals, similar to how polio immunizations are made."[6]
Development
Tayyebeh Mokhber, the first volunteer who receives a shot of COVIran Barakat was the daughter of Mohammad Mokhber director of setad. Minister of Health Saeed Namaki and Vice President for Science and Technology Sorena Sattari participated at the ceremony of vaccine injection. According to reports, there is more than 65,000 Iranians volunteered to test the vaccine and 56 selected people take apart in the first phase of human trials which last 45 to 60 days.[7] The initial phase of human-testing for this vaccine started with the injection for 56 volunteers who were at the age of 18-50.[8][9][10]
The second/third group of volunteers were also injected with the vaccine.[11][12] According to the head of the vaccine production team at the Setad, the results show that this vaccine also neutralizes the British mutated COVID-19 virus.[13][14][15]
In March 2021, the Executive Office of Imam Khomeini's Order began a Phase II–III clinical trial of COVIran Barakat with 280 participants in cities including Tehran, Mashhad, Karaj, Esfahan, Shiraz. According to the allowance of medical equipment department, the second phase coincided with third phase.[16][17] The vaccine has reached its third phase of human-testing;[18] and the first injection(s) of the 3rd phase has begun since 25 April 2021.[19]
As Official in charge of manufacturing Iran Barakat vaccines Mohammad Reza Salehi said, “some neighboring countries tend to enter the third phase of the clinical trial of the Iranian "COVIran Barakat"”. They are reviewing recommended to let them participate.[8]
Production
According to Setad ( the Executive Headquarters of Imam's Directive), under the direct control of the Supreme Leader of Iran, "production of the vaccine developed by one of its companies, Shifa Pharmed, could reach 12 million doses per month, six months after a successful trial ends".[20] On March 15 2021 he stated that EIKO has already a capacity of three million doses per month and that by end of June the capacity will be 15-20 million doses per month.[21][22]
On March 29, 2021, the Tehran Times reported that a capacity of three million doses per month was achieved;[citation needed] and the production line of 25 million doses per month of Iran Koo vaccine was discharged on 26 April 2021.[23]
References
- ^ "Iranians demand a COVID-19 vaccine, not politics, from their leaders". latimes.
- ^ "Coronavirus Tzar Forced to Apologize to Clergy". iranwire.
- ^ Vahdat, Amir (29 December 2020). "Iran begins human trials for locally made coronavirus vaccine". Times of Israel. Retrieved 30 December 2020.
- ^ "IRCT | A double-blind, randomized, placebo-controlled Phase II/III Clinical trial to evaluate the safety and efficacy of COVID-19 inactivated vaccine (Shifa-Pharmed) in a population aged 18 to 75 years". en.irct.ir. Retrieved 2021-04-07.
- ^ 3080 (2021-03-30). "Some foreign states willing to cooperate in COVIran Barakat clinical test: Official". IRNA English. Retrieved 2021-04-07.
{{cite web}}:|last=has numeric name (help) - ^ "Iran begins first human trial of locally made virus vaccine". health.economictimes.indiatimes. 29 December 2019.
- ^ "COVIran Barakat: Iran launches human trials of its COVID vaccine". aljazeera. 29 December 2019.
- ^ a b "Some foreign states willing to cooperate in COVIran Barakat clinical test: Official". irna.
- ^ Human test of Iranian corona vaccine begins / Minister of Health: We are the first vaccinator in Asia with 100 years of experience tasnimnews.com Retrieved 29 December 2020
- ^ End of the injection of phase one (studies) of "Kovoo-Iran Barakat" vaccine yjc.ir Retrieved 16 February 2021
- ^ Start of injecting the Iranian corona vaccine to the second group of volunteers mehrnews.com
- ^ The injection of "Iranian corona vaccine" to the second group of volunteers began tasnimnews.com
- ^ Jalili: The Iranian vaccine neutralizes the British virus yjc.ir
- ^ Iranian vaccine succeeds in neutralizing "British mutated virus" isna.ir
- ^ "Iran Vaccine Boasts Total Protection Against U.K. Covid Strain". bloomberg.
- ^ "Clinical trials of COVIRAN vaccine enter phases 2, 3". isna.
- ^ "واکسن ایران برکت احتمالا تا پایان خرداد ۱۴۰۰ به دست هموطنان میرسد". IRNA.
- ^ The beginning of the third stage of the human test of COVIran Barakat IRINN, Retrieved 21 April 2021
- ^ The third phase of Iran Barakat vaccine was injected YJC, Retrieved 25 April 2021
- ^ "Iran starts human testing of first domestic COVID-19 vaccine". reuters. 29 December 2019.
- ^ "Iran starts mass-production of homegrown coronavirus vaccine". Tehran Times. 2021-03-15. Retrieved 2021-04-07.
- ^ "Iran to kick off production of 3mn doses of COVIRAN". Mehr News Agency. 2021-03-15. Retrieved 2021-04-07.
- ^ The production line of 25 million doses per month of Iran Koo vaccine was cleared, Retrieved 4 May 2021
External links
