JWH-018
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| Clinical data | |
|---|---|
| Routes of administration | smoked, oral, transdermal |
| Legal status | |
| Legal status |
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| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.163.574 |
| Chemical and physical data | |
| Formula | C24H23NO |
| Molar mass | 341.45 g/mol g·mol−1 |
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is an analgesic drug from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with some selectivity for CB2.[1][2][3] It produces effects in animals very similar to those of THC.
On December 15th 2008, it was announced by German pharmaceutical company THC Pharm, that JWH-018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense, in a number of countries around the world since 2002. [4][5][6]
Following a recent triumphant lawsuit the website [(http://www.jwh018.net)] continues to sell this product to the UK and worldwide markets and advertises itself as the worlds cheapest supplier of JWH-018. How long this trend will last is subject to speculation by the popular media.
Legal status
Austria
The Austrian Ministry of Health announced on 18th December 2008 that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance which affects the functions of the body, and the legality of JWH-018 is under review.[7][8][9]
Germany
JWH-018 is illegal in Germany since 22nd of January 2009.[10]
France
JWH-018 is illegal in France since 24th of February 2009.[11]
Netherlands
JWH-018 is "banned" in the Netherlands.[12]
Worldwide
In most other countries JWH-018 remains legal at present, although it might potentially be deemed a controlled substance analogue in certain jurisdictions where very broadly worded drug analogues laws are in force. JWH-018 is unlike any known illegal cannabinoid, and thus is not subject to various analogue acts.
See also
- Spice, a mislabelled mixture of herbs sold commercially as "incense" that also contains undeclared JWH-018.
- JWH-073
- JWH-081
- JWH-200
References
- ^ Aung, M. M. (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence. 60 (2): 133–140. doi:10.1016/S0376-8716(99)00152-0.
{{cite journal}}: Cite has empty unknown parameter:|month=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ US patent 6900236, Alexandros Makriyannis, Hongfeng Deng, "Cannabimimetic indole derivatives", issued 2005-05-31
- ^ US patent 7241799, Alexandros Makriyannis, Hongfeng Deng, "Cannabimimetic indole derivatives", issued 2007-07-10
- ^ Gefährlicher Kick mit Spice (German)
- ^ Erstmals Bestandteile der Modedroge „Spice“ nachgewiesen (German)
- ^ Spice enthält chemischen Wirkstoff (German)
- ^ Kräutermischung "Spice": Gesundheitsministerium stoppt Handel. (German) 18 December 2008
- ^ Austria bans herbal incense 'Spice'
- ^ Gesundheitsministerium setzt Maßnahme zum Verbot von "Spice" (German)
- ^ BGBl I Nr. 3 vom 21.01.2009, 22. BtMÄndV vom 19. Januar 2009, S. 49–50.
- ^ [1]
- ^ Germans say goodbye to herbal high
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